Adaptors for clathrin-mediated traffic

被引:413
作者
Kirchhausen, T
机构
[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
[2] Ctr Blood Res, Boston, MA 02115 USA
关键词
membrane traffic; protein sorting; endocytosis; secretion; AP-1; AP-2; AP-3; arrestin;
D O I
10.1146/annurev.cellbio.15.1.705
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Clathrin-based systems are responsible for a large portion of vesicular traffic originating from the plasma membrane and the trans-Golgi network that reaches the endosomal compartment. The assembly of cytosolic clathrin forms the scaffold required for the local deformation of the membrane and for the formation of coated pits and vesicles. In this process, clathrin interacts in a coordinated fashion with a large number of protein partners. A subset designated clathrin adaptors links integral membrane proteins to the clathrin coat, a process that results in the recruitment of specific cargo proteins to the budding vesicle. This review focuses on the most recent advances dealing with the molecular basis for sorting by clathrin adaptors.
引用
收藏
页码:705 / +
页数:33
相关论文
共 159 条
[51]   A di-leucine-based motif in the cytoplasmic tail of LIMP-II and tyrosinase mediates selective binding of AP-3 [J].
Honing, S ;
Sandoval, IV ;
von Figura, K .
EMBO JOURNAL, 1998, 17 (05) :1304-1314
[52]  
HUANG KM, 1999, IN PRESS EMBO J
[53]   LOCALIZATION OF TGN38 TO THE TRANS-GOLGI NETWORK - INVOLVEMENT OF A CYTOPLASMIC TYROSINE-CONTAINING SEQUENCE [J].
HUMPHREY, JS ;
PETERS, PJ ;
YUAN, LC ;
BONIFACINO, JS .
JOURNAL OF CELL BIOLOGY, 1993, 120 (05) :1123-1135
[54]  
Iannolo G, 1997, CANCER RES, V57, P240
[55]   Mutation in AP-3 δ in the mocha mouse links endosomal transport to storage deficiency in platelets, melanosomes, and synaptic vesicles [J].
Kantheti, P ;
Qiao, XX ;
Diaz, ME ;
Peden, AA ;
Meyer, GE ;
Carskadon, SL ;
Kapfhamer, D ;
Sufalko, D ;
Robinson, MS ;
Noebels, JL ;
Burmeister, M .
NEURON, 1998, 21 (01) :111-122
[56]   CLATHRIN AND ASSOCIATED ASSEMBLY AND DISASSEMBLY PROTEINS [J].
KEEN, JH .
ANNUAL REVIEW OF BIOCHEMISTRY, 1990, 59 :415-438
[58]   CLATHRIN-COATED VESICLES - ISOLATION, DISSOCIATION AND FACTOR-DEPENDENT REASSOCIATION OF CLATHRIN BASKETS [J].
KEEN, JH ;
WILLINGHAM, MC ;
PASTAN, IH .
CELL, 1979, 16 (02) :303-312
[59]   The LDL receptor clustering motif interacts with the clathrin terminal domain in a reverse turn conformation [J].
Kibbey, RG ;
Rizo, J ;
Gierasch, LM ;
Anderson, RGW .
JOURNAL OF CELL BIOLOGY, 1998, 142 (01) :59-67
[60]   STRUCTURAL AND FUNCTIONAL DIVISION INTO 2 DOMAINS OF THE LARGE (100-KDA TO 115-KDA) CHAINS OF THE CLATHRIN-ASSOCIATED PROTEIN COMPLEX AP-2 [J].
KIRCHHAUSEN, T ;
NATHANSON, KL ;
MATSUI, W ;
VAISBERG, A ;
CHOW, EP ;
BURNE, C ;
KEEN, JH ;
DAVIS, AE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (08) :2612-2616