Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus

被引：284

作者：

Belz, GT

Smith, CM

Kleinert, L

Reading, P

Brooks, A

Shortman, K

Carbone, FR

Heath, WR

机构：

[1] Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3050, Australia

[2] Walter & Eliza Hall Inst Med Res, Cooperat Res Ctr Vaccine Technol, Parkville, Vic 3050, Australia

[3] Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic 3010, Australia

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2004年 / 101卷 / 23期

关键词：

lymphocyte; influenza A virus;

D O I：

10.1073/pnas.0402644101

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

During lung infection with virus, airway-derived dendritic cells (DC) have been thought to be the dominant cell type involved in acquisition, transport, and direct antigen presentation for cytotoxic T lymphocyte priming. Contrary to this view, we have found that both an airway-derived CD8alpha(-)CD11b(-) DC subset and distinct CD8alpha(+) lymph node resident DC can present class I-restricted antigens after lung infection with influenza virus or herpes simplex virus 1. Presentation by a nonairway-derived DC population argues that cytotoxic T lymphocyte priming may involve interplay between different DC subsets, not all of which originate within the site of infection.

引用

收藏

页码：8670 / 8675

页数：6

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