Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus

被引：284

作者：

Belz, GT

Smith, CM

Kleinert, L

Reading, P

Brooks, A

Shortman, K

Carbone, FR

Heath, WR

机构：

[1] Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3050, Australia

[2] Walter & Eliza Hall Inst Med Res, Cooperat Res Ctr Vaccine Technol, Parkville, Vic 3050, Australia

[3] Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic 3010, Australia

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2004年 / 101卷 / 23期

关键词：

lymphocyte; influenza A virus;

D O I：

10.1073/pnas.0402644101

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

During lung infection with virus, airway-derived dendritic cells (DC) have been thought to be the dominant cell type involved in acquisition, transport, and direct antigen presentation for cytotoxic T lymphocyte priming. Contrary to this view, we have found that both an airway-derived CD8alpha(-)CD11b(-) DC subset and distinct CD8alpha(+) lymph node resident DC can present class I-restricted antigens after lung infection with influenza virus or herpes simplex virus 1. Presentation by a nonairway-derived DC population argues that cytotoxic T lymphocyte priming may involve interplay between different DC subsets, not all of which originate within the site of infection.

引用

收藏

页码：8670 / 8675

页数：6

相关论文

共 34 条

[1] Epidermal viral immunity induced by CD8α+ dendritic cells but not by Langerhans cells [J].

Allan, RS ;

Smith, CM ;

Belz, GT ;

van Lint, AL ;

Wakim, LM ;

Heath, WR ;

Carbone, FR .

SCIENCE, 2003, 301 (5641) :1925-1928

[2] COMPLEMENT-DEPENDENT NEUTRALIZATION OF INFLUENZA-VIRUS BY A SERUM MANNOSE-BINDING LECTIN [J].

ANDERS, EM ;

HARTLEY, CA ;

READING, PC ;

EZEKOWITZ, RAB .

JOURNAL OF GENERAL VIROLOGY, 1994, 75 :615-622

[3] Mouse type IIFN-producing cells are immature APCs with plasmacytoid morphology [J].

Asselin-Paturel, C ;

Boonstra, A ;

Dalod, M ;

Durand, I ;

Yessaad, N ;

Dezutter-Dambuyant, C ;

Vicari, A ;

O'Garra, A ;

Biron, C ;

Brière, F ;

Trinchieri, G .

NATURE IMMUNOLOGY, 2001, 2 (12) :1144-1150

[4] Dendritic cells and the control of immunity [J].

Banchereau, J ;

Steinman, RM .

NATURE, 1998, 392 (6673) :245-252

[5] Cutting edge:: Conventional CD8α+ dendritic cells are generally involved in priming CTL immunity to viruses [J].

Belz, GT ;

Smith, CM ;

Eichner, D ;

Shortman, K ;

Karupiah, G ;

Carbone, FR ;

Heath, WK .

JOURNAL OF IMMUNOLOGY, 2004, 172 (04) :1996-2000

[6] The CD8α+ dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens [J].

Belz, GT ;

Behrens, GMN ;

Smith, CM ;

Miller, JFAP ;

Jones, C ;

Lejon, K ;

Fathman, CG ;

Mueller, SN ;

Shortman, K ;

Carbone, FR ;

Heath, WR .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (08) :1099-1104

[7] Immunization with a single major histocompatibility complex class I-restricted cytotoxic T-lymphocyte recognition epitope of herpes simplex virus type 2 confers protective immunity [J].

Blaney, JE ;

Nobusawa, E ;

Brehm, MA ;

Bonneau, RH ;

Mylin, LM ;

Fu, TM ;

Kawaoka, Y ;

Tevethia, SS .

JOURNAL OF VIROLOGY, 1998, 72 (12) :9567-9574

[8] CD8+ but not CD8- dendritic cells cross-prime cytotoxic T cells in vivo [J].

den Haan, JMM ;

Lehar, SM ;

Bevan, MJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (12) :1685-1695

[9] Viral infection switches non-plasmacytoid dendritic cells into high interferon producers [J].

Diebold, SS ;

Montoya, M ;

Unger, H ;

Alexopoulou, L ;

Roy, P ;

Haswell, LE ;

Al-Shamkhani, A ;

Flavell, R ;

Borrow, P ;

Sousa, CRE .

NATURE, 2003, 424 (6946) :324-328

[10]

HAVENITH CEG, 1993, ADV EXP MED BIOL, V329, P571

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