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SRC-1 and Wnt signaling act together to specify endoderm and to control cleavage orientation in early C-elegans embryos

被引：125
作者：
Bei, YX
Hogan, J
Berkowitz, LA
Soto, M
Rocheleau, CE
Pang, KM
Collins, J
Mello, CC [1 ]
机构：
[1] Howard Hughes Med Inst, Coconut Grove, FL 33133 USA
[2] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA
[3] Univ New Hampshire, Dept Biochem & Mol Biol, Durham, NH 03824 USA
[4] Univ Tulsa, Dept Biol Sci, Tulsa, OK 74104 USA
来源：
DEVELOPMENTAL CELL | 2002年 / 3卷 / 01期
关键词：
D O I：
10.1016/S1534-5807(02)00185-5
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In early C. elegans embryos, signaling between a posterior blastomere, P2, and a ventral blastomere, EMS, specifies endoderm and orients the division axis of the EMS cell. Although Wnt signaling contributes to this polarizing interaction, no mutants identified to date abolish P2/EMS signaling. Here, we show that two tyrosine kinase-related genes, src-1 and mes-1, are required for the accumulation of phosphotyrosine between P2 and EMS. Moreover, src-1 and mes-1 mutants strongly enhance endoderm and EMS spindle rotation defects associated with Wnt pathway mutants. SRC-1 and MES-1 signal bidirectionally to control cell fate and division orientation in both EMS and P2. Our findings suggest that Wnt and Src signaling function in parallel to control developmental outcomes within a single responding cell.
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页码：113 / 125
页数：13
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