Analytical aspects of mass spectrometry and proteomics

被引:38
作者
Mo, WJ
Karger, BL
机构
[1] Northeastern Univ, Barnett Inst, Boston, MA 02115 USA
[2] Northeastern Univ, Dept Chem, Boston, MA 02115 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1016/S1367-5931(02)00379-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mass spectrometry plays an essential role in proteomics analysis and research. In recent years, it has been increasingly recognized that a key to proteomics using mass spectrometry relies not only on the instrument itself, but also on the analytical strategies and front-end sample-handling techniques. The advances of separations and mass spectrometry are having an increasing impact on the discovery of disease biomarkers and the understanding of cellular processes.
引用
收藏
页码:666 / 675
页数:10
相关论文
共 123 条
[31]   Proteome analysis of low-abundance proteins using multidimensional chromatography and isotope-coded affinity tags [J].
Gygi, SP ;
Rist, B ;
Griffin, TJ ;
Eng, J ;
Aebersold, R .
JOURNAL OF PROTEOME RESEARCH, 2002, 1 (01) :47-54
[32]   Quantitative analysis of complex protein mixtures using isotope-coded affinity tags [J].
Gygi, SP ;
Rist, B ;
Gerber, SA ;
Turecek, F ;
Gelb, MH ;
Aebersold, R .
NATURE BIOTECHNOLOGY, 1999, 17 (10) :994-999
[33]   Facile sequencing of oligosaccharides by matrix-assisted laser desorption/ionisation on a hybrid quadrupole orthogonal acceleration time-of-flight mass spectrometer [J].
Hanrahan, S ;
Charlwood, J ;
Tyldesley, R ;
Langridge, J ;
Bordoll, R ;
Bateman, R ;
Camilleri, P .
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2001, 15 (14) :1141-1151
[34]   A survey of recent research activity in quadrupole ion trap mass spectrometry [J].
Hao, CY ;
March, RE .
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 2001, 212 (1-3) :337-357
[35]   Baseline mass resolution of peptide isobars: A record for molecular mass resolution [J].
He, F ;
Hendrickson, CL ;
Marshall, AG .
ANALYTICAL CHEMISTRY, 2001, 73 (03) :647-650
[36]   Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry [J].
Ho, Y ;
Gruhler, A ;
Heilbut, A ;
Bader, GD ;
Moore, L ;
Adams, SL ;
Millar, A ;
Taylor, P ;
Bennett, K ;
Boutilier, K ;
Yang, LY ;
Wolting, C ;
Donaldson, I ;
Schandorff, S ;
Shewnarane, J ;
Vo, M ;
Taggart, J ;
Goudreault, M ;
Muskat, B ;
Alfarano, C ;
Dewar, D ;
Lin, Z ;
Michalickova, K ;
Willems, AR ;
Sassi, H ;
Nielsen, PA ;
Rasmussen, KJ ;
Andersen, JR ;
Johansen, LE ;
Hansen, LH ;
Jespersen, H ;
Podtelejnikov, A ;
Nielsen, E ;
Crawford, J ;
Poulsen, V ;
Sorensen, BD ;
Matthiesen, J ;
Hendrickson, RC ;
Gleeson, F ;
Pawson, T ;
Moran, MF ;
Durocher, D ;
Mann, M ;
Hogue, CWV ;
Figeys, D ;
Tyers, M .
NATURE, 2002, 415 (6868) :180-183
[37]   Three-dimensional ion mobility TOFMS analysis of electrosprayed biomolecules [J].
Hoaglund, CS ;
Valentine, SJ ;
Sporleder, CR ;
Reilly, JP ;
Clemmer, DE .
ANALYTICAL CHEMISTRY, 1998, 70 (11) :2236-2242
[38]   Coupling ion mobility separations, collisional activation techniques, and multiple stages of MS for analysis of complex peptide mixtures [J].
Hoaglund-Hyzer, CS ;
Lee, YJ ;
Counterman, AE ;
Clemmer, DE .
ANALYTICAL CHEMISTRY, 2002, 74 (05) :992-1006
[39]   Activated ion electron capture dissociation for mass spectral sequencing of larger (42 kDa) proteins [J].
Horn, DM ;
Ge, Y ;
McLafferty, FW .
ANALYTICAL CHEMISTRY, 2000, 72 (20) :4778-4784
[40]   NEW DESORPTION STRATEGIES FOR THE MASS-SPECTROMETRIC ANALYSIS OF MACROMOLECULES [J].
HUTCHENS, TW ;
YIP, TT .
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 1993, 7 (07) :576-580