Analytical aspects of mass spectrometry and proteomics

被引：38

作者：

Mo, WJ

Karger, BL

机构：

[1] Northeastern Univ, Barnett Inst, Boston, MA 02115 USA

[2] Northeastern Univ, Dept Chem, Boston, MA 02115 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2002年 / 6卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S1367-5931(02)00379-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mass spectrometry plays an essential role in proteomics analysis and research. In recent years, it has been increasingly recognized that a key to proteomics using mass spectrometry relies not only on the instrument itself, but also on the analytical strategies and front-end sample-handling techniques. The advances of separations and mass spectrometry are having an increasing impact on the discovery of disease biomarkers and the understanding of cellular processes.

引用

收藏

页码：666 / 675

页数：10

相关论文

共 123 条

[1] The cell as a collection of protein machines: Preparing the next generation of molecular biologists [J].

Alberts, B .

CELL, 1998, 92 (03) :291-294

[2] Axin-mediated CKI phosphorylation of β-catenin at Ser 45:: a molecular switch for the Wnt pathway [J].

Amit, S ;

Hatzubai, A ;

Birman, Y ;

Andersen, JS ;

Ben-Shushan, E ;

Mann, M ;

Ben-Neriah, Y ;

Alkalay, I .

GENES & DEVELOPMENT, 2002, 16 (09) :1066-1076

[3] ISOLATION OF PHOSPHOPROTEINS BY IMMOBILIZED METAL (FE-3+) AFFINITY-CHROMATOGRAPHY [J].

ANDERSSON, L ;

PORATH, J .

ANALYTICAL BIOCHEMISTRY, 1986, 154 (01) :250-254

[4] Matrix assisted laser desorption/ionization coupled with quadrupole/orthogonal acceleration time-of-flight mass spectrometry for protein discovery, identification, and structural analysis [J].

Baldwin, MA ;

Medzihradszky, KF ;

Lock, CM ;

Fisher, B ;

Settineri, TA ;

Burlingame, AL .

ANALYTICAL CHEMISTRY, 2001, 73 (08) :1707-1720

[5] Resolving isomeric peptide mixtures: A combined HPLC/ion mobility-TOFMS analysis of a 4000-component combinatorial library [J].

Barnes, CAS ;

Hilderbrand, AE ;

Valentine, SJ ;

Clemmer, DE .

ANALYTICAL CHEMISTRY, 2002, 74 (01) :26-36

[6] Dynamic range expansion applied to mass spectrometry based on data-dependent selective ion ejection in capillary liquid chromatography Fourier transform ion cyclotron resonance for enhanced proteome characterization [J].

Belov, ME ;

Anderson, GA ;

Angell, NH ;

Shen, YF ;

Tolic, N ;

Udseth, HR ;

Smith, RD .

ANALYTICAL CHEMISTRY, 2001, 73 (21) :5052-5060

[7] A new technique for unbiased external ion accumulation in a quadrupole two-dimensional ion trap for electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry [J].

Belov, ME ;

Nikolaev, EN ;

Alving, K ;

Smith, RD .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2001, 15 (14) :1172-1180

[8] Controlled ion fragmentation in a 2-D quadrupole ion trap for external ion accumulation in ESI FTICR mass spectrometry [J].

Belov, ME ;

Gorshkov, MV ;

Udseth, HR ;

Smith, RD .

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2001, 12 (12) :1312-1319

[9] Design and performance of an ESI interface for selective external ion accumulation coupled to a Fourier transform ion cyclotron mass spectrometer [J].

Belov, ME ;

Nikolaev, EN ;

Anderson, GA ;

Udseth, HR ;

Conrads, TP ;

Veenstra, TD ;

Masselon, CD ;

Gorshkov, MV ;

Smith, RD .

ANALYTICAL CHEMISTRY, 2001, 73 (02) :253-261

[10] Electron capture dissociation of multiply-charged oxygenated cations. A nonergodic process [J].

Cerda, BA ;

Horn, DM ;

Breuker, K ;

Carpenter, BK ;

McLafferty, FW .

EUROPEAN MASS SPECTROMETRY, 1999, 5 (05) :335-338

← 1 2 3 4 5 6 7 8 9 10 →