Dare to be different:: Asymmetric cell division in Drosophila, C-elegans and vertebrates

被引：341

作者：

Betschinger, J

Knoblich, JA

机构：

[1] Res Inst Mol Pathol, IMP, A-1030 Vienna, Austria

[2] Austrian Acad Sci, Inst Mol Biotechnol, IMBA, A-1030 Vienna, Austria

来源：

CURRENT BIOLOGY | 2004年 / 14卷 / 16期

基金：

奥地利科学基金会;

关键词：

D O I：

10.1016/j.cub.2004.08.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

One widespread mechanism for the generation of diverse cell types is the unequal inheritance of cell fate determinants. Several such determinants have been identified in the fruitfly Drosophila melanogaster and the worm Caenorhabditis elegans and the molecular machinery responsible for their asymmetric segregation is beginning to be unraveled. To divide asymmetrically, cells establish an axis of polarity, orient the mitotic spindle along this axis and localize cell fate determinants to one side of the cell. During cytokinesis, determinants are then segregated into one of the two daughter cells where they direct cell fate. Here, we outline the steps and factors that are involved in this process in Drosophila and C. elegans and discuss their potential conservation in vertebrates.

引用

收藏

页码：R674 / R685

页数：12

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