Regulation of protein phosphatase-1

被引：157

作者：

Aggen, JB

Nairn, AC

Chamberlin, R ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Chem, Irvine, CA 92697 USA

[2] Rockefeller Univ, Mol & Cellular Neurosci Lab, New York, NY 10021 USA

来源：

CHEMISTRY & BIOLOGY | 2000年 / 7卷 / 01期

关键词：

D O I：

10.1016/S1074-5521(00)00069-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reversible protein phosphorylation is a major regulatory mechanism of intracellular signal transduction. Protein phosphatase 1 (PP1) is one of four major types of serine-threonine phosphatases mediating signaling pathways, but the means by which its activity is modulated has only recently begun to come into focus.

引用

收藏

页码：R13 / R23

页数：11

相关论文

共 86 条

[21] Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1 [J].

Egloff, MP ;

Johnson, DF ;

Moorhead, G ;

Cohen, PTW ;

Cohen, P ;

Barford, D .

EMBO JOURNAL, 1997, 16 (08) :1876-1887

[22] CRYSTAL-STRUCTURE OF THE CATALYTIC SUBUNIT OF HUMAN PROTEIN PHOSPHATASE-1 AND ITS COMPLEX WITH TUNGSTATE [J].

EGLOFF, MP ;

COHEN, PTW ;

REINEMER, P ;

BARFORD, D .

JOURNAL OF MOLECULAR BIOLOGY, 1995, 254 (05) :942-959

[23] Multiple structural elements define the specificity of recombinant human inhibitor-1 as a protein phosphatase-1 inhibitor [J].

Endo, S ;

Zhou, XZ ;

Connor, J ;

Wang, B ;

Shenolikar, S .

BIOCHEMISTRY, 1996, 35 (16) :5220-5228

[24]

FENG ZH, 1991, J BIOL CHEM, V266, P23796

[25] PROTEIN PHOSPHATASE TYPE-1 IN MAMMALIAN-CELL MITOSIS - CHROMOSOMAL LOCALIZATION AND INVOLVEMENT IN MITOTIC EXIT [J].

FERNANDEZ, A ;

BRAUTIGAN, DL ;

LAMB, NJC .

JOURNAL OF CELL BIOLOGY, 1992, 116 (06) :1421-1430

[26] A KINETIC-ANALYSIS OF THE EFFECTS OF INHIBITOR-1 AND INHIBITOR-2 ON THE ACTIVITY OF PROTEIN PHOSPHATASE-1 [J].

FOULKES, JG ;

STRADA, SJ ;

HENDERSON, PJF ;

COHEN, P .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1983, 132 (02) :309-313

[27] A new isoform of human myosin phosphatase targeting/regulatory subunit (MYPT2): cDNA cloning, tissue expression, and chromosomal mapping [J].

Fujioka, M ;

Takahashi, N ;

Odai, H ;

Araki, S ;

Ichikawa, K ;

Feng, JH ;

Nakamura, M ;

Kaibuchi, K ;

Hartshorne, DJ ;

Nakano, T ;

Ito, M .

GENOMICS, 1998, 49 (01) :59-68

[28] PROTEIN-PHOSPHORYLATION AND DEPHOSPHORYLATION IN MAMMALIAN CENTRAL-NERVOUS-SYSTEM [J].

GIRAULT, JA .

NEUROCHEMISTRY INTERNATIONAL, 1993, 23 (01) :1-25

[29]

GIRAULT JA, 1989, J BIOL CHEM, V264, P21748

[30] 3-DIMENSIONAL STRUCTURE OF THE CATALYTIC SUBUNIT OF PROTEIN SERINE/THREONINE PHOSPHATASE-1 [J].

GOLDBERG, J ;

HUANG, HB ;

KWON, YG ;

GREENGARD, P ;

NAIRN, AC ;

KURIYAN, J .

NATURE, 1995, 376 (6543) :745-753

← 1 2 3 4 5 6 7 8 9 →