Decompensation of cardiac hypertrophy: Cellular mechanisms and novel therapeutic targets

被引：178

作者：

Diwan, Abhinav ^{[1
]}

Dorn, Gerald W., II ^{[1
]}

机构：

[1] Univ Cincinnati, Ctr Mol Cardiovasc Res, Cincinnati, OH 45221 USA

来源：

PHYSIOLOGY | 2007年 / 22卷

关键词：

D O I：

10.1152/physiol.00033.2006

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Cardiac hypertrophy leads to heart failure, and both conditions can ultimately prove lethal. Here, traditional and novel mechanisms relating hypertrophy and heart failure are described at the physiological, cellular, and molecular levels. The rational application of these mechanistic considerations to therapeutics targeting hypertrophy and heart failure is discussed.

引用

页码：56 / 64

页数：9

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