Autophagy: Dual roles in life and death?

被引：845

作者：

Baehrecke, EH ^{[1
]}

机构：

[1] Univ Maryland, Maryland Biotechnol Inst, Ctr Biosyst Res, College Pk, MD 20742 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2005年 / 6卷 / 06期

基金：

美国国家航空航天局; 美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm1666

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Autophagy is an evolutionarily conserved mechanism for the degradation of cellular components in the cytoplasm, and serves as a cell survival mechanism in starving cells. Recent studies indicate that autophagy also functions in cell death, but the precise role of this catabolic process in dying cells is not clear. Here I discuss the possible roles for autophagy in dying cells and how understanding the relationship between autophagy, cell survival and cell death is important for health and development.

引用

页码：505 / 510

页数：7

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