T-cell regulation by CD28 and CTLA-4

被引：689

作者：

Alegre, ML

Frauwirth, KA

Thompson, CB

机构：

[1] Dept Med, Rheumatol Sect, Chicago, IL 60637 USA

[2] Comm Immunol, Chicago, IL 60637 USA

[3] Univ Penn, Abramson Family Canc Res Inst, Dept Canc Biol, Sch Med, Philadelphia, PA 19104 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2001年 / 1卷 / 03期

关键词：

D O I：

10.1038/35105024

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Activation of T lymphocytes is thought to require at least two signals, one delivered by the T-cell receptor complex after antigen recognition, and one provided on engagement of co-stimulatory receptors, such as CD28. Recent studies are providing clues as to the specific signalling roles of co-stimulatory receptors. Furthermore, superimposition of inhibitory signals, such as those delivered by cytotoxic T-lymphocyte antigen 4 (CTLA-4), leads to a complex network of positive and negative co-stimulatory signals, the integration of which modulates immune responses.

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页码：220 / 228

页数：9

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共 96 条

[71]

Rulifson IC, 1997, J IMMUNOL, V158, P658

[72] c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation [J].

Sabapathy, K ;

Kallunki, T ;

David, JP ;

Graef, I ;

Karin, M ;

Wagner, EF .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (03) :317-328

[73] JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development [J].

Sabapathy, K ;

Hu, YL ;

Kallunki, T ;

Schreiber, M ;

David, JP ;

Jochum, W ;

Wagner, EF ;

Karin, M .

CURRENT BIOLOGY, 1999, 9 (03) :116-125

[74] Tyrosine phosphatase SHP-2 binding to CTLA-4: Absence of direct YVKM/YFIP motif recognition [J].

Schneider, H ;

Rudd, CE .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 269 (01) :279-283

[75] T-CELL ANTIGEN CD28 BINDS TO THE GRB-2/SOS COMPLEX, REGULATORS OF P21(RAS) [J].

SCHNEIDER, H ;

CAI, YC ;

PRASAD, KVS ;

SHOELSON, SE ;

RUDD, CE .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1995, 25 (04) :1044-1050

[76] CTLA-4 BINDING TO THE LIPID KINASE PHOSPHATIDYLINOSITOL 3-KINASE IN T-CELLS [J].

SCHNEIDER, H ;

PRASAD, KVS ;

SHOELSON, SE ;

RUDD, CE .

JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (01) :351-355

[77] Structural basis for co-stimulation by the human CTLA-4/B7-2 complex [J].

Schwartz, JCD ;

Zhang, XW ;

Fedorov, AA ;

Nathenson, SG ;

Almo, SC .

NATURE, 2001, 410 (6828) :604-608

[78] Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation [J].

Shan, XC ;

Czar, MJ ;

Bunnell, SC ;

Liu, PH ;

Liu, YS ;

Schwartzberg, PL ;

Wange, RL .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (18) :6945-6957

[79] Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2 [J].

Shiratori, T ;

Miyatake, S ;

Ohno, H ;

Nakaseko, C ;

Isono, K ;

Bonifacino, JS ;

Saito, T .

IMMUNITY, 1997, 6 (05) :583-589

[80] In vivo blockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance [J].

Sotomayor, EM ;

Borrello, I ;

Tubb, E ;

Allison, JP ;

Levitsky, HI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (20) :11476-11481

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