T-cell regulation by CD28 and CTLA-4

被引：689

作者：

Alegre, ML

Frauwirth, KA

Thompson, CB

机构：

[1] Dept Med, Rheumatol Sect, Chicago, IL 60637 USA

[2] Comm Immunol, Chicago, IL 60637 USA

[3] Univ Penn, Abramson Family Canc Res Inst, Dept Canc Biol, Sch Med, Philadelphia, PA 19104 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2001年 / 1卷 / 03期

关键词：

D O I：

10.1038/35105024

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Activation of T lymphocytes is thought to require at least two signals, one delivered by the T-cell receptor complex after antigen recognition, and one provided on engagement of co-stimulatory receptors, such as CD28. Recent studies are providing clues as to the specific signalling roles of co-stimulatory receptors. Furthermore, superimposition of inhibitory signals, such as those delivered by cytotoxic T-lymphocyte antigen 4 (CTLA-4), leads to a complex network of positive and negative co-stimulatory signals, the integration of which modulates immune responses.

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页码：220 / 228

页数：9

相关论文

共 96 条

[1]

Bachmann MF, 1999, J IMMUNOL, V163, P1128

[2] CD4+CD25high regulatory cells in human peripheral blood [J].

Baecher-Allan, C ;

Brown, JA ;

Freeman, GJ ;

Hafler, DA .

JOURNAL OF IMMUNOLOGY, 2001, 167 (03) :1245-1253

[3] The inhibitory function of CTLA-4 does not require its tyrosine phosphorylation [J].

Baroja, ML ;

Luxenberg, D ;

Chau, T ;

Ling, V ;

Strathdee, CA ;

Carreno, BM ;

Madrenas, J .

JOURNAL OF IMMUNOLOGY, 2000, 164 (01) :49-55

[4] BCL-X, A BCL-2-RELATED GENE THAT FUNCTIONS AS A DOMINANT REGULATOR OF APOPTOTIC CELL-DEATH [J].

BOISE, LH ;

GONZALEZGARCIA, M ;

POSTEMA, CE ;

DING, LY ;

LINDSTEN, T ;

TURKA, LA ;

MAO, XH ;

NUNEZ, G ;

THOMPSON, CB .

CELL, 1993, 74 (04) :597-608

[5] Interaction of the cytoplasmic tail of CTLA-4 (CD152) with a clathrin-associated protein is negatively regulated by tyrosine phosphorylation [J].

Bradshaw, JD ;

Lu, P ;

Leytze, G ;

Rodgers, J ;

Schieven, GL ;

Bennett, KL ;

Linsley, PS ;

Kurtz, SE .

BIOCHEMISTRY, 1997, 36 (50) :15975-15982

[6] A THEORY OF SELF-NONSELF DISCRIMINATION [J].

BRETSCHER, P ;

COHN, M .

SCIENCE, 1970, 169 (3950) :1042-+

[7] A NEW MEMBER OF THE IMMUNOGLOBULIN SUPERFAMILY - CTLA-4 [J].

BRUNET, JF ;

DENIZOT, F ;

LUCIANI, MF ;

ROUXDOSSETO, M ;

SUZAN, M ;

MATTEI, MG ;

GOLSTEIN, P .

NATURE, 1987, 328 (6127) :267-270

[8] Cutting edge:: Distinct motifs within CD28 regulate T cell proliferation and induction of Bcl-XL [J].

Burr, JS ;

Savage, NDL ;

Messah, GE ;

Kimzey, SL ;

Shaw, AS ;

Arch, RH ;

Green, JM .

JOURNAL OF IMMUNOLOGY, 2001, 166 (09) :5331-5335

[9] SELECTIVE CD28PYMNM MUTATIONS IMPLICATE PHOSPHATIDYLINOSITOL 3-KINASE IN CD86-CD28-MEDIATED COSTIMULATION [J].

CAI, YC ;

CEFAI, D ;

SCHNEIDER, H ;

RAAB, M ;

NABAVI, N ;

RUDD, CE .

IMMUNITY, 1995, 3 (04) :417-426

[10] Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH4-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70 [J].

Calvo, CR ;

Amsen, D ;

Kruisbeek, AM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (10) :1645-1653

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