Functional analysis of proteins involved in Plasmodium falciparum merozoite invasion of red blood cells

被引：82

作者：

Cowman, AF ^{[1
]}

Baldi, DL

Healer, J

Mills, KE

O'Donnell, RA

Reed, MB

Triglia, T

Wickham, ME

Crabb, BS

机构：

[1] PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia

[2] Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic, Australia

来源：

FEBS LETTERS | 2000年 / 476卷 / 1-2期

关键词：

malaria; vaccine antigen; targeted gene; disruption; Plasmodium falciparum;

D O I：

10.1016/S0014-5793(00)01703-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Plasmodium falciparum causes the most lethal form of malaria in humans and is responsible for over two million deaths per year, The development of a vaccine against this parasite is an urgent priority and potential protein targets include those on the surface of the asexual merozoite stage, the form that invades the host erythrocyte, The development of methods to transfect P, falciparum has enabled the construction of gain-of-function and loss-of-function mutants and provided new strategies to analyse the role of parasite proteins, In this review, we describe the use of this technology to examine the role of merozoite antigens in erythrocyte invasion and to address their potential as vaccine candidates. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V, All rights reserved.

引用

页码：84 / 88

页数：5

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