Presenilins and Alzheimer's disease

被引：48

作者：

Kim, TW

Tanzi, RE

机构：

[1] Genetics and Aging Unit, Massachusetts General Hospital, Charlestown, MA 02129

来源：

CURRENT OPINION IN NEUROBIOLOGY | 1997年 / 7卷 / 05期

关键词：

D O I：

10.1016/S0959-4388(97)80089-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Mutations in the genes encoding the presenilins cause the majority of early-onset cases of Alzheimer's disease (AD). The identification of the presenilin genes has provided new opportunities for elucidating the molecular mechanisms underlying the etiology and pathogenesis of AD. Recent progress has been made in attempts to understand the normal and pathological functions of the presenilins, emphasizing the effects of presenilin familial AD mutations on the amyloid beta-protein precursor, the presenilins themselves, and apoptotic cell death.

引用

页码：683 / 688

页数：6

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