IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex

被引：437

作者：

Chackerian, Alissa A. ^{[1
]}

Oldham, Elizabeth R. ^{[1
]}

Murphy, Erin E. ^{[1
]}

Schmitz, Jochen ^{[1
]}

Pflanz, Stefan ^{[1
]}

Kastelein, Robert A. ^{[1
]}

机构：

[1] DNAX Res, Schering Plough Biopharma, Discovery Res, Palo Alto, CA 94304 USA

来源：

JOURNAL OF IMMUNOLOGY | 2007年 / 179卷 / 04期

关键词：

D O I：

10.4049/jimmunol.179.4.2551

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IL-33 (IL-F11) is a recently described member of the IL-1 family of cytokines that stimulates the generation of cells, cytokines, and Igs characteristic of a type 2 immune response. IL-33 mediates signal transduction through ST2, a receptor expressed on Th2 and mast cells. In this study, we demonstrate that IL-33 and ST2 form a complex with IL-1R accessory protein (IL-IRAcP), a signaling receptor subunit that is also a member of the IL-1R complex. Additionally, IL-IRAcP is required for IL-33-induced in vivo effects, and IL-33-mediated signal transduction can be inhibited by dominant-negative IL-1RAcP. The implications of this shared usage of IL-1RAcP by IL-1(a and 13). and IL-33 are discussed.

引用

页码：2551 / 2555

页数：5

共 21 条

[11] Acute eosinophilic pneumonia with increased soluble ST2 in serum and bronchoalveolar lavage fluid [J].

Oshikawa, K ;

Kuroiwa, K ;

Tokunaga, T ;

Kato, T ;

Hagihara, SI ;

Tominaga, SI ;

Sugiyama, Y .

RESPIRATORY MEDICINE, 2001, 95 (06) :532-533

[12] Suppression of autoimmune arthritis in interleukin-1-deficient mice in which T cell activation is impaired due to low levels of CD40 ligand and OX40 expression on T cells [J].

Saijo, S ;

Asano, M ;

Horai, R ;

Yamamoto, H ;

Iwakura, Y .

ARTHRITIS AND RHEUMATISM, 2002, 46 (02) :533-544

[13] IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines [J].

Schmitz, J ;

Owyang, A ;

Oldham, E ;

Song, YL ;

Murphy, E ;

McClanahan, TK ;

Zurawski, G ;

Moshrefi, M ;

Qin, JZ ;

Li, XX ;

Gorman, DM ;

Bazan, JF ;

Kastelein, RA .

IMMUNITY, 2005, 23 (05) :479-490

[14] Serum levels of the interleukin-1 receptor family member ST2 predict mortality and clinical outcome in acute myocardial infarction [J].

Shimpo, M ;

Morrow, DA ;

Weinberg, EO ;

Sabatine, MS ;

Murphy, SA ;

Antman, EM ;

Lee, RT .

CIRCULATION, 2004, 109 (18) :2186-2190

[15] A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis [J].

Sutton, Caroline ;

Brereton, Corinna ;

Keogh, Brian ;

Mills, Kingston H. G. ;

Lavelle, Ed C. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (07) :1685-1691

[16] The increase in serum soluble ST2 protein upon acute exacerbation of idiopathic pulmonary fibrosis [J].

Tajima, S ;

Oshikawa, K ;

Tominaga, S ;

Sugiyama, Y .

CHEST, 2003, 124 (04) :1206-1214

[17] Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-κB and MAPKs [J].

Towne, JE ;

Garka, KE ;

Renshaw, BR ;

Virca, GD ;

Sims, JE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (14) :13677-13688

[18] T1/ST2 - an IL-1 receptor-like modulator of immune responses [J].

Trajkovic, V ;

Sweet, MJ ;

Xu, DM .

CYTOKINE & GROWTH FACTOR REVIEWS, 2004, 15 (2-3) :87-95

[19] Expression and regulation of ST2, an interleukin-1 receptor family member, in cardiomyocytes and myocardial infarction [J].

Weinberg, EO ;

Shimpo, M ;

De Keulenaer, GW ;

MacGillivray, C ;

Tominaga, S ;

Solomon, SD ;

Rouleau, JL ;

Lee, RT .

CIRCULATION, 2002, 106 (23) :2961-2966

[20] Co-expression of mRNA for type I and type II interleukin-1 receptors and the IL-1 receptor accessory protein correlates to IL-1 responsiveness [J].

Wesche, H ;

Neumann, D ;

Resch, K ;

Martin, MU .

FEBS LETTERS, 1996, 391 (1-2) :104-108

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