IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex

被引：437

作者：

Chackerian, Alissa A. ^{[1
]}

Oldham, Elizabeth R. ^{[1
]}

Murphy, Erin E. ^{[1
]}

Schmitz, Jochen ^{[1
]}

Pflanz, Stefan ^{[1
]}

Kastelein, Robert A. ^{[1
]}

机构：

[1] DNAX Res, Schering Plough Biopharma, Discovery Res, Palo Alto, CA 94304 USA

来源：

JOURNAL OF IMMUNOLOGY | 2007年 / 179卷 / 04期

关键词：

D O I：

10.4049/jimmunol.179.4.2551

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IL-33 (IL-F11) is a recently described member of the IL-1 family of cytokines that stimulates the generation of cells, cytokines, and Igs characteristic of a type 2 immune response. IL-33 mediates signal transduction through ST2, a receptor expressed on Th2 and mast cells. In this study, we demonstrate that IL-33 and ST2 form a complex with IL-1R accessory protein (IL-IRAcP), a signaling receptor subunit that is also a member of the IL-1R complex. Additionally, IL-IRAcP is required for IL-33-induced in vivo effects, and IL-33-mediated signal transduction can be inhibited by dominant-negative IL-1RAcP. The implications of this shared usage of IL-1RAcP by IL-1(a and 13). and IL-33 are discussed.

引用

页码：2551 / 2555

页数：5

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