Met, metastasis, motility and more

被引：2231

作者：

Birchmeier, C

Birchmeier, W

Gherardi, E

Vande Woude, GF

机构：

[1] Van Andel Res Inst, Grand Rapids, MI 49503 USA

[2] Max Delbruck Ctr Mol Med, Dept Neurosci, D-13122 Berlin, Germany

[3] Max Delbruck Ctr Mol Med, Dept Canc Res, D-13122 Berlin, Germany

[4] MRC Ctr, Cambridge CB2 2QH, England

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2003年 / 4卷 / 12期

关键词：

D O I：

10.1038/nrm1261

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Hepatocyte growth factor/scatter factor and its receptor, the tyrosine kinase Met, arose late in evolution and are unique to vertebrates. In spite of this, Met uses molecules such as Gab1 - homologues of which are present in Caenorhabditis elegans and Drosophila melanogaster for downstream signalling. Pivotal roles for Met in development and cancer have been established: Met controls cell migration and growth in embryogenesis; it also controls growth, invasion and metastasis in cancer cells; and activating Met mutations predispose to human cancer.

引用

页码：915 / 925

页数：11

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