Switching and signaling at the telomere

被引：1769

作者：

Blackburn, EH ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA

来源：

CELL | 2001年 / 106卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0092-8674(01)00492-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review describes the structure of telomeres, the protective DNA-protein complexes at eukaryotic chromosomal ends, and several molecular mechanisms involved in telomere functions. Also discussed are cellular responses to compromising the functions of telomeres and of telomerase, which synthesizes telomeric DNA.

引用

页码：661 / 673

页数：13

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