Fibulins: physiological and disease perspectives

被引：255

作者：

Argraves, WS

Greene, LM

Cooley, MA

Gallagher, WM

机构：

[1] Med Univ S Carolina, Dept Cell Biol, Charleston, SC 29425 USA

[2] Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Dept Pharmacol, Dublin 4, Ireland

来源：

EMBO REPORTS | 2003年 / 4卷 / 12期

关键词：

D O I：

10.1038/sj.embor.7400033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The fibulins are a family of proteins that are associated with basement membranes and elastic extracellular matrix fibres. This review summarizes findings from studies of animal models of fibulin deficiency, human fibulin gene mutations, human tumours and injury models that have advanced our understanding of the normal and pathological roles of members of this formerly obscure family.

引用

页码：1127 / 1131

页数：5