7-Pyrrolidinyl- and 7-piperidinyl-5-aryl-pyrrolo[2,3-d] pyrimidines -: Potent inhibitors of the tyrosine kinase c-Src

被引:38
作者
Altmann, E [1 ]
Missbach, M [1 ]
Green, J [1 ]
Susa, M [1 ]
Wagenknecht, HA [1 ]
Widler, L [1 ]
机构
[1] Novartis Pharma Res, Arthrit & Bone Metab Therapeut Area, CH-4002 Basel, Switzerland
关键词
D O I
10.1016/S0960-894X(01)00080-4
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
7-Heterocyclyl-5-aryl-pyrrolo[2,3-d]pyrimidines represent a new class of highly potent and selective inhibitors of the tyrosine kinase pp60(c-Src). (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:853 / 856
页数:4
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