7-alkyl- and 7-cycloalkyl-5-aryl-pyrrolo[2,3-d]pyrimidines -: potent inhibitors of the tyrosine kinase c-Src

被引：47

作者：

Widler, L ^{[1
]}

Green, J ^{[1
]}

Missbach, M ^{[1
]}

Susa, M ^{[1
]}

Altmann, E ^{[1
]}

机构：

[1] Novartis Pharma Res, Arthrit & Bone Metab Therapeut Area, CH-4002 Basel, Switzerland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(01)00079-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

7-Substituted-5-aryl-pyrrolo[2,3-d]pyrimidines have been prepared starting from alpha -bromoacetophenones. These compounds represent a novel class of potent inhibitors of the tyrosine kinase pp60(c-Src) with good specificity towards other tyrosine kinases (EGF-R, v-Abl). (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：849 / 852

页数：4

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