A decade of caspases

被引：949

作者：

Degterev, A ^{[1
]}

Boyce, M ^{[1
]}

Yuan, JY ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

来源：

ONCOGENE | 2003年 / 22卷 / 53期

关键词：

caspase; apoptosis; protease;

D O I：

10.1038/sj.onc.1207107

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Caspases are a family of cysteine proteases that play important roles in regulating apoptosis. A decade of research has generated a wealth of information on the signal transduction pathways mediated by caspases, the distinct functions of individual caspases and the mechanisms by which caspases mediate apoptosis and a variety of physiological and pathological processes.

引用

页码：8543 / 8567

页数：25

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