A prudent path forward for genomic engineering and germline gene modification

被引：417

作者：

Baltimore, David ^{[1
]}

Berg, Paul ^{[2
]}

Botchan, Michael ^{[3
,4
]}

Carroll, Dana ^{[5
]}

Charo, R. Alta ^{[6
]}

Church, George ^{[7
]}

Corn, Jacob E. ^{[4
]}

Daley, George Q. ^{[8
,9
]}

Doudna, Jennifer A. ^{[4
,10
,11
]}

Fenner, Marsha ^{[4
]}

Greely, Henry T. ^{[12
]}

Jinek, Martin ^{[13
]}

Martin, G. Steven ^{[14
]}

Penhoet, Edward ^{[15
]}

Puck, Jennifer ^{[16
]}

Sternberg, Samuel H. ^{[17
]}

Weissman, Jonathan S. ^{[4
,18
]}

Yamamoto, Keith R. ^{[4
,19
]}

机构：

[1] CALTECH, Pasadena, CA 91125 USA

[2] Stanford Univ, Sch Med, Stanford, CA 94305 USA

[3] Univ Calif Berkeley, Berkeley, CA 94720 USA

[4] Univ Calif Berkeley, Innovat Genom Initiat, Berkeley, CA 94720 USA

[5] Univ Utah, Sch Med, Dept Biochem, Salt Lake City, UT 84112 USA

[6] Univ Wisconsin, Sch Law, Sch Med & Publ Hlth, Dept Med Hist & Bioeth, Madison, WI 53706 USA

[7] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[8] Boston Childrens Hosp, Boston, MA 02115 USA

[9] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA

[10] Univ Calif Berkeley, Howard Hughes Med Inst, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[11] Univ Calif Berkeley, Howard Hughes Med Inst, Dept Chem, Berkeley, CA 94720 USA

[12] Ctr Law & Biosci, Stanford, CA 94305 USA

[13] Univ Zurich, Dept Biochem, CH-8057 Zurich, Switzerland

[14] Univ Calif Berkeley, Coll Letters & Sci, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[15] Alta Partners, Embarcadero Ctr 1, San Francisco, CA 94111 USA

[16] Univ Calif San Francisco, Sch Med, Dept Pediat, San Francisco, CA 94143 USA

[17] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[18] Univ Calif San Francisco, Howard Hughes Med Inst, Dept Cellular & Mol Pharmacol, San Francisco, CA 94158 USA

[19] UCSF Sch Med, San Francisco, CA 94158 USA

来源：

SCIENCE | 2015年 / 348卷 / 6230期

关键词：

GENERATION;

D O I：

10.1126/science.aab1028

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

[No abstract available]

引用

页码：36 / 38

页数：3

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