Molecular mechanisms of tumor vascularization

被引：91

作者：

Auguste, P ^{[1
]}

Lemiere, S ^{[1
]}

Larrieu-Lahargue, F ^{[1
]}

Bikfalvi, A ^{[1
]}

机构：

[1] Univ Bordeaux 1, Inst Natl Sante & Rech Med EMI 0113, Mol Angiogenesis Lab, F-33405 Talence, France

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2005年 / 54卷 / 01期

关键词：

tumor vascularization; angiogenesis research; tumor therapy;

D O I：

10.1016/j.critrevonc.2004.11.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor angiogenesis is a fast growing sub-domain of angiogenesis research and tumor biology. Basic mechanisms have been unraveled and many key players identified. For many years, tumor vascularization was explained solely by the ingrowth of new vessels into the tumor from preexisting one's. However, in recent years, additional mechanisms have been recognized. These include angioblasts recruitment, cooption, vasculogenic mimicry and mosaic vessels. These different mechanisms may exist concomitantly in the same tumor or may be selectively involved in a specific tumor type or host environment. In this article, we will review, in depth, these different mechanisms and also discuss some aspects of anti-angiogenic tumor therapy. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：53 / 61

页数：9

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