Pax6 lights-up the way for eye development

被引：195

作者：

Ashery-Padan, R ^{[1
]}

Gruss, P

机构：

[1] Tel Aviv Univ, Sackler Sch Med, Dept Human Genet & Mol Med, IL-69978 Tel Aviv, Israel

[2] Max Planck Inst Biophys Chem, Dept Mol Cell Biol, D-37077 Gottingen, Germany

来源：

CURRENT OPINION IN CELL BIOLOGY | 2001年 / 13卷 / 06期

关键词：

D O I：

10.1016/S0955-0674(00)00274-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent reports have exposed the temporal and spatial functions of the transcription factor Pax6 in the developing vertebrate eye. Pax6 is demonstrated to play essential roles in successive steps triggering lens differentiation while in the retina it functions to maintain multipotency and proliferation of retinal progenitor cells. These findings, together with the identification of Pax6 protein partners and downstream targets, pave the way for future work aimed to understand the molecular mechanism of eye development.

引用

页码：706 / 714

页数：9

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