Systemic administration of Argatroban reduces secondary brain damage in a rat model of intracerebral hemorrhage: Histopathological assessment

被引：27

作者：

Nagatsuna, T ^{[1
]}

Nomura, S ^{[1
]}

Suehiro, E ^{[1
]}

Fujisawa, H ^{[1
]}

Koizumi, H ^{[1
]}

Suzuki, M ^{[1
]}

机构：

[1] Yamaguchi Univ, Sch Med, Dept Neurosurg, Ube, Yamaguchi 7558505, Japan

来源：

CEREBROVASCULAR DISEASES | 2005年 / 19卷 / 03期

关键词：

Argatroban; brain edema; inflammatory cell; intracerebral hemorrhage; reactive astrocytes; thrombin;

D O I：

10.1159/000083466

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This study investigated the effects of argatroban, a thrombin inhibitor, on brain edema and inflammation in a rat intracerebral hemorrhage (ICH) model. ICH was induced by injecting collagenase IV into the right caudate nucleus. Argatroban was administered intraperitoneally. Argatroban reduced brain edema from 44.6 to 14.3 mul at 72 h. Infiltration of polymorphonuclear leukocytes at 24 h and monocyte/macrophage at 24 and 72 h was significantly suppressed by argatroban. Argatroban did not increase the volume of hematoma. Systemic administration of argatroban reduced secondary brain damage including edema and inflammation in a rat ICH model. Copyright (C) 2005 S. Karger AG, Basel.

引用

页码：192 / 200

页数：9

共 35 条

[11]

ISHII H, 1986, BLOOD, V67, P362

[12] Thrombin-activated human endothelial cells support monocyte adhesion in vitro following expression of intercellular adhesion molecule-1 (ICAM-1; CD54) and vascular cell adhesion molecule-1 (VCAM-1; CD106) [J].

Kaplanski, G ;

Marin, V ;

Fabrigoule, M ;

Boulay, V ;

Benoliel, AM ;

Bongrand, P ;

Kaplanski, S ;

Farnarier, C .

BLOOD, 1998, 92 (04) :1259-1267

[13]

Kaplanski G, 1997, J IMMUNOL, V158, P5435

[14] THE COMBINATION OF THROMBIN INHIBITOR AND THROMBOXANE SYNTHASE INHIBITOR ON EXPERIMENTAL THROMBOSIS AND BLEEDING [J].

KAWAI, H ;

TAMAO, Y .

THROMBOSIS RESEARCH, 1995, 80 (05) :429-434

[15] SELECTIVE-INHIBITION OF THROMBIN BY (2R,4R)-4-METHYL-1-[N2-[(3-METHYL-1,2,3,4-TETRAHYDRO-8-QUINOLINYL)SULFONYL]-L-ARGINYL)]-2-PIPERIDINECARBOXYLIC ACID [J].

KIKUMOTO, R ;

TAMAO, Y ;

TEZUKA, T ;

TONOMURA, S ;

HARA, H ;

NINOMIYA, K ;

HIJIKATA, A ;

OKAMOTO, S .

BIOCHEMISTRY, 1984, 23 (01) :85-90

[16] Delayed argatroban treatment reduces edema in a rat model of intracerebral hemorrhage [J].

Kitaoka, T ;

Hua, Y ;

Xi, GH ;

Hoff, JT ;

Keep, RF .

STROKE, 2002, 33 (12) :3012-3018

[17] The role of the coagulation cascade in brain edema formation after intracerebral hemorrhage [J].

Lee, KR ;

Betz, AL ;

Kim, S ;

Keep, RF ;

Hoff, JT .

ACTA NEUROCHIRURGICA, 1996, 138 (04) :396-400

[18] INTRACEREBRAL INFUSION OF THROMBIN AS A CAUSE OF BRAIN EDEMA [J].

LEE, KR ;

BETZ, AL ;

KEEP, RF ;

CHENEVERT, TL ;

KIM, S ;

HOFF, JT .

JOURNAL OF NEUROSURGERY, 1995, 83 (06) :1045-1050

[19] Mechanisms of edema formation after intracerebral hemorrhage: Effects of thrombin on cerebral blood flow, blood-brain barrier permeability, and cell survival in a rat model [J].

Lee, KR ;

Kawai, N ;

Kim, S ;

Sagher, O ;

Hoff, JT .

JOURNAL OF NEUROSURGERY, 1997, 86 (02) :272-278

[20] Edema from intracerebral hemorrhage: The role of thrombin [J].

Lee, KR ;

Colon, GP ;

Betz, AL ;

Keep, RF ;

Kim, S ;

Hoff, JT .

JOURNAL OF NEUROSURGERY, 1996, 84 (01) :91-96

← 1 2 3 4 →