Systemic administration of Argatroban reduces secondary brain damage in a rat model of intracerebral hemorrhage: Histopathological assessment

被引：27

作者：

Nagatsuna, T ^{[1
]}

Nomura, S ^{[1
]}

Suehiro, E ^{[1
]}

Fujisawa, H ^{[1
]}

Koizumi, H ^{[1
]}

Suzuki, M ^{[1
]}

机构：

[1] Yamaguchi Univ, Sch Med, Dept Neurosurg, Ube, Yamaguchi 7558505, Japan

来源：

CEREBROVASCULAR DISEASES | 2005年 / 19卷 / 03期

关键词：

Argatroban; brain edema; inflammatory cell; intracerebral hemorrhage; reactive astrocytes; thrombin;

D O I：

10.1159/000083466

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This study investigated the effects of argatroban, a thrombin inhibitor, on brain edema and inflammation in a rat intracerebral hemorrhage (ICH) model. ICH was induced by injecting collagenase IV into the right caudate nucleus. Argatroban was administered intraperitoneally. Argatroban reduced brain edema from 44.6 to 14.3 mul at 72 h. Infiltration of polymorphonuclear leukocytes at 24 h and monocyte/macrophage at 24 and 72 h was significantly suppressed by argatroban. Argatroban did not increase the volume of hematoma. Systemic administration of argatroban reduced secondary brain damage including edema and inflammation in a rat ICH model. Copyright (C) 2005 S. Karger AG, Basel.

引用

页码：192 / 200

页数：9

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