Development, expansion, and use of a stroke clinical trials resource for novel exploratory analyses

被引：76

作者：

Ali, Myzoon ^{[1
,11
]}

Bath, Philip ^{[2
]}

Brady, Marian ^{[1
]}

Davis, Stephen ^{[3
]}

Diener, Hans-Christoph ^{[4
]}

Donnan, Geoffrey

Fisher, Marc ^{[5
]}

Hacke, Werner ^{[6
]}

Hanley, Daniel F. ^{[7
]}

Luby, Marie ^{[8
]}

Tsivgoulis, G. ^{[9
]}

Wahlgren, Nils ^{[10
]}

Warach, Steven ^{[8
]}

Lees, Kennedy R. ^{[11
]}

机构：

[1] Glasgow Caledonian Univ, NMAHP Res Unit, Glasgow G4 0BA, Lanark, Scotland

[2] Univ Nottingham, Inst Neurosci, Nottingham NG7 2RD, England

[3] Univ Melbourne, Royal Melbourne Hosp, Dept Neurol, Melbourne, Vic 3050, Australia

[4] Univ Duisburg Essen, Dept Neurol, Essen, Germany

[5] Univ Massachusetts, Sch Med, Dept Neurol, Worcester, MA USA

[6] Heidelberg Univ, Dept Neurol, Heidelberg, Germany

[7] Johns Hopkins Med Inst, Div Brain Injury Outcomes, Baltimore, MD 21205 USA

[8] NINDS, Stroke Diagnost & Therapeut Sect, Bethesda, MD 20892 USA

[9] Democritus Univ Thrace, Dept Neurol, Alexandroupolis, Greece

[10] Karolinska Hosp, Dept Clin Neurosci, S-10401 Stockholm, Sweden

[11] Univ Glasgow, Western Infirm, Inst Cardiovasc Med Sci, Glasgow G11 6NT, Lanark, Scotland

来源：

INTERNATIONAL JOURNAL OF STROKE | 2012年 / 7卷 / 02期

关键词：

database; secondary analysis; stroke; trial design; RANDOMIZED CONTROLLED-TRIAL; ACUTE ISCHEMIC-STROKE; ARCHIVE VISTA; ASPIRIN; THROMBOLYSIS; CLOPIDOGREL; DIPYRIDAMOLE; PREVENTION; OUTCOMES; REGISTRY;

D O I：

10.1111/j.1747-4949.2011.00735.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction Analysis of reliable registry data can direct future research to influence clinical care. Data from the Virtual International Stroke Trials Archive have been used to test hypotheses and inform trial design. We sought to expand Virtual International Stroke Trials Archive into a broader stroke resource with new opportunities for research and international collaboration. Methods Using procedures initially developed for an acute stroke trial archive, we invited trialists to lodge data on rehabilitation, secondary prevention, intracerebral haemorrhage, imaging, and observational stroke studies. Results We have extended Virtual International Stroke Trials Archive into six subsections: Virtual International Stroke Trials Archive-Acute (n = 28 190 patients' data), Virtual International Stroke Trials Archive-Rehab (n = 10 194), Virtual International Stroke Trials Archive-intracerebral haemorrhage (n = 1829), Virtual International Stroke Trials Archive-Prevention, Virtual International Stroke Trials Archive-Imaging (n = 1300), and Virtual International Stroke Trials Archive-Plus (n = 6573). Enrollment continues, with commitments for the contribution of six further trials to Virtual International Stroke Trials Archive-Prevention, 13 trials to Virtual International Stroke Trials Archive-Rehab, and one registry to Virtual International Stroke Trials Archive-Plus. Data on age, type of stroke, medical history, outcomes by modified Rankin scale and Barthel Index (BI), mortality, and adverse events are available for analyses. The Virtual International Stroke Trials Archive network encourages the development of young investigators and provides opportunities for international peer review and collaboration. Conclusions Application of the original Virtual International Stroke Trials Archive concepts beyond acute stroke trials can extend the value of clinical research at low cost, without threatening commercial or intellectual property interests. This delivers valuable research output to inform the efficiency of future stroke research. We invite stroke researchers to participate actively in Virtual International Stroke Trials Archive and encourage the extension of Virtual International Stroke Trials Archive principles to other disease areas.

引用

页码：133 / 138

页数：6

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