Activation by locus control regions?

被引：119

作者：

Grosveld, F ^{[1
]}

机构：

[1] Erasmus Univ, Ctr Med Genet, Dept Genet & Cell Biol, NL-3000 DR Rotterdam, Netherlands

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1999年 / 9卷 / 02期

关键词：

D O I：

10.1016/S0959-437X(99)80023-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

On the basis of homologous recombination experiments to delete the murine beta-globin locus control region (LCR) in embryonic stem cells, it was recently suggested that the LCR is not required for the activation of the murine beta-globin locus. This conclusion is in direct contradiction to the findings and conclusions that have been obtained with the human beta-globin LCR; thus the murine and human LCR may functionally be different or there may be a different interpretation of the results.

引用

页码：152 / 157

页数：6

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