The Drosophila Fab-7 chromosomal element conveys epigenetic inheritance during mitosis and meiosis

被引：301

作者：

Cavalli, G ^{[1
]}

Paro, R ^{[1
]}

机构：

[1] Univ Heidelberg, ZMBH, D-69120 Heidelberg, Germany

来源：

CELL | 1998年 / 93卷 / 04期

关键词：

D O I：

10.1016/S0092-8674(00)81181-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polycomb group (PcG) and trithorax group (trxG) gene products are responsible for the maintenance of repressed and active expression patterns of many developmentally important regulatory genes including the homeotic genes. In Drosophila embryos, Polycomb protein and the trxG protein GAGA factor colocalize at the Fab-7 DNA element of the bithorax complex. In transgenic lines, the Fab-7 element induces extensive silencing on a flanking GAL4-driven lacZ reporter and mini-white genes. However, a short single pulse of GAL4 during embryogenesis is sufficient to release PcG-dependent silencing from the transgene. Such an activated state of Fab-7 is mitotically inheritable through development and can be transmitted in a GAL4-independent manner to the subsequent generations through female meiosis. Thus, Fab-7 is a switchable chromosomal element, which can convey memory of epigenetically determined active and repressed chromatin states.

引用

页码：505 / 518

页数：14

共 51 条

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