First examples of peptidomimetic inhibitors of interleukin-1 beta converting enzyme

被引：45

作者：

Dolle, RE ^{[1
]}

Prouty, CP ^{[1
]}

Prasad, CVC ^{[1
]}

Cook, E ^{[1
]}

Saha, A ^{[1
]}

Ross, TM ^{[1
]}

Salvino, JM ^{[1
]}

Helaszek, CT ^{[1
]}

Ator, MA ^{[1
]}

机构：

[1] SANOFI WINTHROP INC,COLLEGEVILLE,PA 19426

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1996年 / 39卷 / 13期

关键词：

PROTEASE; PRECURSOR;

D O I：

10.1021/jm9601516

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：2438 / 2440

页数：3

共 24 条

[11] ASPARTYL ALPHA-((1-PHENYL-3-(TRIFLUOROMETHYL)PYRAZOL-5-YL)OXY)METHYL KETONES AS INTERLEUKIN-1-BETA CONVERTING-ENZYME INHIBITORS - SIGNIFICANCE OF THE P-1 AND P-3 AMIDO NITROGENS FOR ENZYME-PEPTIDE INHIBITOR BINDING [J].

DOLLE, RE ;

SINGH, J ;

RINKER, J ;

HOYER, D ;

PRASAD, CVC ;

GRAYBILL, TL ;

SALVINO, JM ;

HELASZEK, CT ;

MILLER, RE ;

ATOR, MA .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (23) :3863-3866

[12] ASPARTYL ALPHA-((DIPHENYLPHOSPHINYL)OXY)METHYL KETONES AS NOVEL INHIBITORS OF INTERLEUKIN-1-BETA CONVERTING-ENZYME - UTILITY OF THE DIPHENYLPHOSPHINIC ACID LEAVING GROUP FOR THE INHIBITION OF CYSTEINE PROTEASES [J].

DOLLE, RE ;

SINGH, J ;

WHIPPLE, D ;

OSIFO, IK ;

SPEIER, G ;

GRAYBILL, TL ;

GREGORY, JS ;

HARRIS, AL ;

HELASZEK, CT ;

MILLER, RE ;

ATOR, MA .

JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (02) :220-222

[13] P-1 ASPARTATE-BASED PEPTIDE ALPHA-((2,6-DICHLOROBENZOYL)OXY)METHYL KETONES AS POTENT TIME-DEPENDENT INHIBITORS OF INTERLEUKIN-1-BETA-CONVERTING ENZYME [J].

DOLLE, RE ;

HOYER, D ;

PRASAD, CVC ;

SCHMIDT, SJ ;

HELASZEK, CT ;

MILLER, RE ;

ATOR, MA .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (05) :563-564

[14]

HOWARD AD, 1991, J IMMUNOL, V147, P2964

[15] NEW COUPLING REAGENTS IN PEPTIDE CHEMISTRY [J].

KNORR, R ;

TRZECIAK, A ;

BANNWARTH, W ;

GILLESSEN, D .

TETRAHEDRON LETTERS, 1989, 30 (15) :1927-1930

[16] IDENTIFICATION OF A MONOCYTE SPECIFIC PRE-INTERLEUKIN 1-BETA CONVERTASE ACTIVITY [J].

KOSTURA, MJ ;

TOCCI, MJ ;

LIMJUCO, G ;

CHIN, J ;

CAMERON, P ;

HILLMAN, AG ;

CHARTRAIN, NA ;

SCHMIDT, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (14) :5227-5231

[17]

MILLER DK, 1993, IMMUNOSUPPRESSIVE AN, V696, P133

[18]

SLEATH PR, 1990, J BIOL CHEM, V265, P14526

[19] A NOVEL HETERODIMERIC CYSTEINE PROTEASE IS REQUIRED FOR INTERLEUKIN-1-BETA PROCESSING IN MONOCYTES [J].

THORNBERRY, NA ;

BULL, HG ;

CALAYCAY, JR ;

CHAPMAN, KT ;

HOWARD, AD ;

KOSTURA, MJ ;

MILLER, DK ;

MOLINEAUX, SM ;

WEIDNER, JR ;

AUNINS, J ;

ELLISTON, KO ;

AYALA, JM ;

CASANO, FJ ;

CHIN, J ;

DING, GJF ;

EGGER, LA ;

GAFFNEY, EP ;

LIMJUCO, G ;

PALYHA, OC ;

RAJU, SM ;

ROLANDO, AM ;

SALLEY, JP ;

YAMIN, TT ;

LEE, TD ;

SHIVELY, JE ;

MACCROSS, M ;

MUMFORD, RA ;

SCHMIDT, JA ;

TOCCI, MJ .

NATURE, 1992, 356 (6372) :768-774

[20] DETERMINATION OF THE RATE-CONSTANT OF ENZYME MODIFICATION BY MEASURING THE SUBSTRATE REACTION IN THE PRESENCE OF THE MODIFIER [J].

TIAN, WX ;

TSOU, CL .

BIOCHEMISTRY, 1982, 21 (05) :1028-1032

← 1 2 3 →