Role of endothelin-1 in lung disease

被引：228

作者：

Fagan, KA ^{[1
]}

McMurtry, IF ^{[1
]}

Rodman, DM ^{[1
]}

机构：

[1] Univ Colorado, Hlth Sci Ctr, Div Pulm Sci & Crit Care Med, Cardiovasc Pulm Res Lab, Denver, CO 80262 USA

来源：

RESPIRATORY RESEARCH | 2001年 / 2卷 / 02期

关键词：

asthma; endothelin; fibrosis; inflammation; pulmonary hypertension;

D O I：

10.1186/rr44

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Endothelin-1 (ET-1) is a 21 amino acid peptide with diverse biological activity that has been implicated in numerous diseases. ET-1 is a potent mitogen regulator of smooth muscle tone, and inflammatory mediator that may play a key role in diseases of the airways, pulmonary circulation, and inflammatory lung diseases, both acute and chronic. This review will focus on the biology of ET-1 and its role in lung disease.

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收藏

页码：90 / 101

页数：12

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