Role of endothelin-1 in lung disease

被引：228

作者：

Fagan, KA ^{[1
]}

McMurtry, IF ^{[1
]}

Rodman, DM ^{[1
]}

机构：

[1] Univ Colorado, Hlth Sci Ctr, Div Pulm Sci & Crit Care Med, Cardiovasc Pulm Res Lab, Denver, CO 80262 USA

来源：

RESPIRATORY RESEARCH | 2001年 / 2卷 / 02期

关键词：

asthma; endothelin; fibrosis; inflammation; pulmonary hypertension;

D O I：

10.1186/rr44

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Endothelin-1 (ET-1) is a 21 amino acid peptide with diverse biological activity that has been implicated in numerous diseases. ET-1 is a potent mitogen regulator of smooth muscle tone, and inflammatory mediator that may play a key role in diseases of the airways, pulmonary circulation, and inflammatory lung diseases, both acute and chronic. This review will focus on the biology of ET-1 and its role in lung disease.

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页码：90 / 101

页数：12

相关论文

共 175 条

[1] Endothelin in bronchoalveolar lavage fluid is increased in lung-transplanted patients [J].

Aarnio, P ;

Tukiainen, P ;

Taskinen, E ;

Harjula, A ;

Fyhrquist, F .

SCANDINAVIAN JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 1996, 30 (3-4) :113-116

[2]

Abraham DJ, 1997, AM J PATHOL, V151, P831

[3] CONSTITUTIVE EXPRESSION OF ENDOTHELIN IN BRONCHIAL EPITHELIAL-CELLS OF PATIENTS WITH SYMPTOMATIC AND ASYMPTOMATIC ASTHMA AND MODULATION BY HISTAMINE AND INTERLEUKIN-1 [J].

ACKERMAN, V ;

CARPI, S ;

BELLINI, A ;

VASSALLI, G ;

MARINI, M ;

MATTOLI, S .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1995, 96 (05) :618-627

[4] Vascular remodeling and ET-1 expression in rat strains with different responses to chronic hypoxia [J].

Aguirre, JI ;

Morrell, NW ;

Long, L ;

Clift, P ;

Upton, PD ;

Polak, JM ;

Wilkins, MR .

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2000, 278 (05) :L981-L987

[5] Studies on the expression of endothelin, its receptor subtypes, and converting enzymes in lung cancer and in human bronchial epithelium [J].

Ahmed, SI ;

Thompson, J ;

Coulson, JM ;

Woll, PJ .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2000, 22 (04) :422-431

[6]

Alanen K, 2000, HISTOPATHOLOGY, V36, P161

[7] Expression of endothelial nitric oxide synthase, inducible nitric oxide synthase, and endothelin-1 in lungs of subjects who died with ARDS [J].

Albertine, KH ;

Wang, ZM ;

Michael, JR .

CHEST, 1999, 116 (01) :101S-102S

[8] Stimulation of colorectal cancer cell line growth by ET-1 and its inhibition by ETA antagonists [J].

Ali, H ;

Loizidou, M ;

Dashwood, M ;

Savage, F ;

Sheard, C ;

Taylor, I .

GUT, 2000, 47 (05) :685-688

[9] EFFECT OF ISCHEMIA REPERFUSION OR HYPOXIA REOXYGENATION ON LUNG VASCULAR-PERMEABILITY AND RESISTANCE [J].

ALLISON, RC ;

KYLE, J ;

ADKINS, WK ;

PRASAD, VR ;

MCCORD, JM ;

TAYLOR, AE .

JOURNAL OF APPLIED PHYSIOLOGY, 1990, 69 (02) :597-603

[10]

AOKI T, 1994, ANN ALLERGY, V73, P365

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