Magnetite-loaded polymeric micelles as ultrasensitive magnetic-resonance probes

被引：430

作者：

Ai, H

Flask, C

Weinberg, B

Shuai, X

Pagel, MD

Farrell, D

Duerk, J

Gao, JM ^{[1
]}

机构：

[1] Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Dept Radiol, Cleveland, OH 44106 USA

[3] Case Western Reserve Univ, Dept Phys, Cleveland, OH 44106 USA

来源：

ADVANCED MATERIALS | 2005年 / 17卷 / 16期

关键词：

D O I：

10.1002/adma.200401904

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Increased contrast in magnetic resonance imaging (MRI) is accomplished using polymeric micelles loaded with superparamagnetic iron oxide (SPIO) nanoparticles encapsulated in biocompatible, biodegradable poly(F-caprolactone) -b-poly(ethylene glycol) (PCL-b-PEG) copolymers (see Figure). The loaded micelles show significantly improved T-2 relaxivities and remarkable MRI detection sensitivity.

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页码：1949 / +

页数：5

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