Interactions between monoamines, glutamate, and GABA in schizophrenia: New evidence

被引：538

作者：

Carlsson, A ^{[1
]}

Waters, N ^{[1
]}

Holm-Waters, S ^{[1
]}

Tedroff, J ^{[1
]}

Nilsson, M ^{[1
]}

Carlsson, ML ^{[1
]}

机构：

[1] Univ Gothenburg, Inst Physiol & Pharmacol, Gothenburg, Sweden

来源：

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY | 2001年 / 41卷

关键词：

dopamine; noradrenaline; serotonin; movement disorders; stabilization;

D O I：

10.1146/annurev.pharmtox.41.1.237

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In spite of its proven heuristic value, the dopamine hypothesis of schizophrenia is now yielding to a multifactorial view, in which the other monoamines as well as glutamate and GABA are included, with a focus on neurotransmitter interactions in complex neurocircuits. The primary lesion(s) in schizophrenia does not necessarily involve any of these neurotransmitters directly but could deal with a more general defect, such as a faulty connectivity of developmental origin. Nevertheless, a precise identification of neurotransmitter aberrations in schizophrenia will probably provide clues for a better understanding of the disease and for the development of new treatment and prevention strategies.

引用

页码：237 / 260

页数：24

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