Prions: Health scare and biological challenge

被引：117

作者：

Aguzzi, A ^{[1
]}

Montrasio, F ^{[1
]}

Kaeser, PS ^{[1
]}

机构：

[1] Univ Zurich, Inst Neuropathol, CH-8091 Zurich, Switzerland

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2001年 / 2卷 / 02期

关键词：

D O I：

10.1038/35052063

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Although human prion diseases are rare, the incidence of 'new variant' Creutzfeldt-Jakob disease in the United Kingdom is increasing exponentially. Given that this disease is probably the result of infection with bovine prions, understanding how prions replicate - and how to counteract their action - has become a central issue for public health. What are the links between the bovine and human prion diseases, and how do prions reach and damage the central nervous system?

引用

页码：118 / 126

页数：9

共 91 条

[1] Spongiform encephalopathies - Between cows and monkeys [J].

Aguzzi, A .

NATURE, 1996, 381 (6585) :734-735

[2] Spongiform encephalopathies - The prion's perplexing persistence [J].

Aguzzi, A ;

Weissmann, C .

NATURE, 1998, 392 (6678) :763-764

[3] Neuro-immune connection in spread of prions in the body? [J].

Aguzzi, A .

LANCET, 1997, 349 (9054) :742-743

[4] Spongiform encephalopathies - A suspicious signature [J].

Aguzzi, A ;

Weissmann, C .

NATURE, 1996, 383 (6602) :666-667

[5] Protein conformation dictates prion strain [J].

Aguzzi, A .

NATURE MEDICINE, 1998, 4 (10) :1125-1126

[6] Prion research: the next frontiers [J].

Aguzzi, A ;

Weissmann, C .

NATURE, 1997, 389 (6653) :795-798

[7] Post-exposure prophylaxis after accidental prion inoculation [J].

Aguzzi, A ;

Collinge, J .

LANCET, 1997, 350 (9090) :1519-1520

[8]

Aguzzi A, 2000, HAEMATOLOGICA, V85, P3

[9] Transmission dynamics and epidemiology of BSE in British cattle [J].

Anderson, RM ;

Donnelly, CA ;

Ferguson, NM ;

Woolhouse, MEJ ;

Watt, CJ ;

Udy, HJ ;

MaWhinney, S ;

Dunstan, SP ;

Southwood, TRE ;

Wilesmith, JW ;

Ryan, JBM ;

Hoinville, LJ ;

Hillerton, JE ;

Austin, AR ;

Wells, GAH .

NATURE, 1996, 382 (6594) :779-788

[10] Evidence for an alternative direct route of access for the scrapie agent to the brain bypassing the spinal cord [J].

Baldauf, E ;

Beekes, M ;

Diringer, H .

JOURNAL OF GENERAL VIROLOGY, 1997, 78 :1187-1197

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