Protein conformation dictates prion strain

被引：15

作者：

Aguzzi, A ^{[1
]}

机构：

[1] Univ Spital Zurich, Inst Neuropathol, CH-8091 Zurich, Switzerland

来源：

NATURE MEDICINE | 1998年 / 4卷 / 10期

关键词：

D O I：

10.1038/2621

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new conformation-based immunoassay provides a smart and sensitive way of differentiating between strains of prions, the infectious particles believed to cause spongiform encephalopathy (pages 1157–1165 ).

引用

页码：1125 / 1126

页数：2

共 11 条

[1] BIOCHEMICAL AND PHYSICAL-PROPERTIES OF THE PRION PROTEIN FROM 2 STRAINS OF THE TRANSMISSIBLE MINK ENCEPHALOPATHY AGENT [J].

BESSEN, RA ;

MARSH, RF .

JOURNAL OF VIROLOGY, 1992, 66 (04) :2096-2101

[2] Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent [J].

Bruce, ME ;

Will, RG ;

Ironside, JW ;

McConnell, I ;

Drummond, D ;

Suttie, A ;

McCardle, L ;

Chree, A ;

Hope, J ;

Birkett, C ;

Cousens, S ;

Fraser, H ;

Bostock, CJ .

NATURE, 1997, 389 (6650) :498-501

[3] Prion diseases - BSE and prions: Uncertainties about the agent [J].

Chesebro, B .

SCIENCE, 1998, 279 (5347) :42-43

[4] Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD [J].

Collinge, J ;

Sidle, KCL ;

Meads, J ;

Ironside, J ;

Hill, AF .

NATURE, 1996, 383 (6602) :685-690

[5] Straining the prion hypothesis [J].

Farquhar, CF ;

Somerville, RA ;

Bruce, ME .

NATURE, 1998, 391 (6665) :345-346

[6] The same prion strain causes vCJD and BSE [J].

Hill, AF ;

Desbruslais, M ;

Joiner, S ;

Sidle, KCL ;

Gowland, I ;

Collinge, J ;

Doey, LJ ;

Lantos, P .

NATURE, 1997, 389 (6650) :448-450

[7] Molecular basis of phenotypic variability in sporadic Creutzfeldt-Jakob disease [J].

Parchi, P ;

Castellani, R ;

Capellari, S ;

Ghetti, B ;

Young, K ;

Chen, SG ;

Farlow, M ;

Dickson, DW ;

Sima, AAF ;

Trojanowski, JQ ;

Petersen, RB ;

Gambetti, P .

ANNALS OF NEUROLOGY, 1996, 39 (06) :767-778

[8] NOVEL PROTEINACEOUS INFECTIOUS PARTICLES CAUSE SCRAPIE [J].

PRUSINER, SB .

SCIENCE, 1982, 216 (4542) :136-144

[9] Eight prion strains have PrPSc molecules with different conformations [J].

Safar, J ;

Wille, H ;

Itrri, V ;

Groth, D ;

Serban, H ;

Torchia, M ;

Cohen, FE ;

Prusiner, SB .

NATURE MEDICINE, 1998, 4 (10) :1157-1165

[10] Evidence for the conformation of the pathologic isoform of the prion protein enciphering and propagating prion diversity [J].

Telling, GC ;

Parchi, P ;

DeArmond, SJ ;

Cortelli, P ;

Montagna, P ;

Gabizon, R ;

Mastrianni, J ;

Lugaresi, E ;

Gambetti, P ;

Prusiner, SB .

SCIENCE, 1996, 274 (5295) :2079-2082

← 1 2 →