Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD

被引：1445

作者：

Collinge, J

Sidle, KCL

Meads, J

Ironside, J

Hill, AF

机构：

[1] WESTERN GEN HOSP, NATL CJD SURVEILLANCE UNIT, EDINBURGH EH4 2XU, MIDLOTHIAN, SCOTLAND

[2] ST MARYS HOSP, DEPT NEUROL, LONDON W2 1NY, ENGLAND

来源：

NATURE | 1996年 / 383卷 / 6602期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/383685a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Strains of transmissible spongiform encephalopathies are distinguished by differing physicochemical properties of PrPSc, the disease-related isoform of prion protein, which can be maintained on transmission to transgenic mice. 'New variant' Creutzfeldt-Jakob disease (CJD) has strain characteristics distinct from other types of CJD and which resemble those of BSE transmitted to mice, domestic cat and macaque, consistent with BSE being the source of this new disease. Strain characteristics revealed here suggest that the prion protein may itself encode disease phenotype.

引用

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页码：685 / 690

页数：6

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