Efficacy of Lactobacillus casei treatment on small bowel injury in chronic low-dose aspirin users: a pilot randomized controlled study

被引：96

作者：

Endo, Hiroki ^{[1
]}

Higurashi, Takuma ^{[2
]}

Hosono, Kunihiro ^{[1
]}

Sakai, Eiji ^{[1
]}

Sekino, Yusuke ^{[1
]}

Iida, Hiroshi ^{[1
]}

Sakamoto, Yasunari ^{[1
]}

Koide, Tomoko ^{[1
]}

Takahashi, Hirokazu ^{[1
]}

Yoneda, Masato ^{[1
]}

Tokoro, Chikako ^{[1
]}

Inamori, Masahiko ^{[1
]}

Abe, Yasunobu ^{[1
]}

Nakajima, Atsushi ^{[1
]}

机构：

[1] Yokohama City Univ, Sch Med, Div Gastroenterol, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan

[2] Yokohama Rosai Hosp, Dept Gastroenterol, Kohoku Ku, Yokohama, Kanagawa, Japan

来源：

JOURNAL OF GASTROENTEROLOGY | 2011年 / 46卷 / 07期

关键词：

Low-dose aspirin; Capsule endoscopy; Small bowel; Probiotics; DRUG-INDUCED ENTEROPATHY; ENDOSCOPY SCORING INDEX; VIDEO CAPSULE ENDOSCOPY; FACTOR-ALPHA PRODUCTION; ESCHERICHIA-COLI; CROHNS-DISEASE; INTESTINAL PERMEABILITY; PLUS OMEPRAZOLE; CLINICAL-TRIAL; STRAIN SHIROTA;

D O I：

10.1007/s00535-011-0410-1

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Few studies have investigated measures to prevent small bowel injuries induced by aspirin. Our aim was to evaluate the effect of probiotic treatment on the small bowel injuries induced by chronic low-dose aspirin use. Thirty-five patients who took low-dose enteric-coated aspirin 100 mg daily (for more than 3 months) plus omeprazole 20 mg daily and were diagnosed as having unexplained iron deficiency anemia participated in this prospective randomized controlled trial. We assigned the patients to receive probiotic treatment with Lactobacillus casei for 3 months (L. casei group) or not receive the probiotic (control group). Patients underwent capsule endoscopy (CE) before and after treatment. Twenty-five patients, including 13 in the L. casei group and 12 in the control group, underwent the full analysis. Significant decreases in the number of mucosal breaks and the CE score were observed at the 3-month evaluation in the L. casei group as compared with the results in the control group (P = 0.039). The change from the baseline in the median number of mucosal breaks in the L. casei group was -2, as compared with 0.5 in the control group. The change from the baseline in the median CE score in the L. casei group was -228 compared with -4 in the control group (P = 0.026). Co-administration of L. casei is effective for the treatment of aspirin-associated small bowel injury.

引用

页码：894 / 905

页数：12

共 42 条

[11] QUANTITATIVE ANALYSIS OF LOW-DOSE ASPIRIN-ASSOCIATED SMALL BOWEL INJURY USING A CAPSULE ENDOSCOPY SCORING INDEX [J].

Endo, Hiroki ;

Hosono, Kunihiro ;

Higurashi, Takuma ;

Sakai, Eiji ;

Iida, Hiroshi ;

Sakamoto, Yasunari ;

Fujita, Koji ;

Takahashi, Hirokazu ;

Koide, Tomoko ;

Yoneda, Masato ;

Tokoro, Chikako ;

Inamori, Masahiko ;

Abe, Yasunobu ;

Matsuhashi, Nobuyuki ;

Nakajima, Atsushi .

DIGESTIVE ENDOSCOPY, 2011, 23 (01) :56-61

[12] Characteristics of small bowel injury in symptomatic chronic low-dose aspirin users: the experience of two medical centers in capsule endoscopy [J].

Endo, Hiroki ;

Hosono, Kunihiro ;

Inamori, Masahiko ;

Nozaki, Yuichi ;

Yoneda, Kyoko ;

Fujita, Koji ;

Takahashi, Hirokazu ;

Yoneda, Masato ;

Abe, Yasunobu ;

Kirikoshi, Hiroyuki ;

Kobayashi, Noritoshi ;

Kubota, Kensuke ;

Saito, Satoru ;

Ohya, Tomohiko ;

Hisatomi, Kantaro ;

Teratani, Takuma ;

Matsuhashi, Nobuyuki ;

Nakajima, Atsushi .

JOURNAL OF GASTROENTEROLOGY, 2009, 44 (06) :544-549

[13] Incidence of Small Bowel Injury Induced by Low-Dose Aspirin: A Crossover Study Using Capsule Endoscopy in Healthy Volunteers [J].

Endo, Hiroki ;

Hosono, Kunihiro ;

Inamori, Masahiko ;

Kato, Shingo ;

Nozaki, Yuichi ;

Yoneda, Kyoko ;

Akiyama, Tomoyuki ;

Fujita, Koji ;

Takahashi, Hirokazu ;

Yoneda, Masato ;

Abe, Yasunobu ;

Kirikoshi, Hiroyuki ;

Kobayashi, Noritoshi ;

Kubota, Kensuke ;

Saito, Satoru ;

Matsuhashi, Nobuyuki ;

Nakajima, Atsushi .

DIGESTION, 2009, 79 (01) :44-51

[14] Distribution of small intestinal mucosal injuries as a result of NSAID administration [J].

Fujimori, Shunji ;

Gudis, Katya ;

Takahashi, Yoko ;

Seo, Tsuguhiko ;

Yamada, Yukie ;

Ehara, Akihito ;

Kobayashi, Tsuyoshi ;

Mitsui, Keigo ;

Yonezawa, Masaoki ;

Tanaka, Shu ;

Tatsuguchi, Atsushi ;

Sakamoto, Choitsu .

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2010, 40 (06) :504-510

[15] Prevention of nonsteroidal anti-inflammatory drug-induced small-intestinal injury by prostaglandin: a pilot randomized controlled trial evaluated by capsule endoscopy [J].

Fujimori, Shunji ;

Seo, Tsuguhiko ;

Gudis, Katya ;

Ehara, Akihito ;

Kobayashi, Tsuyoshi ;

Mitsui, Keigo ;

Yonezawa, Masaoki ;

Tanaka, Shu ;

Tatsuguchi, Atsushi ;

Sakamoto, Choitsu .

GASTROINTESTINAL ENDOSCOPY, 2009, 69 (07) :1339-1346

[16] PROBIOTICS IN HUMAN MEDICINE [J].

FULLER, R .

GUT, 1991, 32 (04) :439-442

[17] Small bowel mucosal injury is reduced in healthy subjects treated with celecoxib compared with ibuprofen plus omeprazole, as assessed by video capsule endoscopy [J].

Goldstein, J. L. ;

Eisen, G. M. ;

Lewis, B. ;

Gralnek, I. M. ;

Aisenberg, J. ;

Bhadra, P. ;

Berger, M. F. .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2007, 25 (10) :1211-1222

[18] Video capsule endoscopy to prospectively assess small bowel injury with celecoxib, naproxen plus omeprazole, and placebo [J].

Goldstein, JL ;

Eisen, GM ;

Lewis, B ;

Gralnek, IM ;

Zlotnick, S ;

Fort, JG .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2005, 3 (02) :133-141

[19] ASPIRIN AND THE STOMACH [J].

GRAHAM, DY ;

SMITH, JL .

ANNALS OF INTERNAL MEDICINE, 1986, 104 (03) :390-398

[20] Development of a capsule endoscopy scoring index for small bowel mucosal inflammatory change [J].

Gralnev, I. M. ;

Defranchis, R. ;

Seidman, E. ;

Leighton, J. A. ;

Legnani, P. ;

Lewis, B. S. .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2008, 27 (02) :146-154

← 1 2 3 4 5 →