A quantitative trait locus associated with cognitive ability in children

被引：96

作者：

Chorney, MJ

Chorney, K

Seese, N

Owen, MJ

Daniels, J

McGuffin, P

Thompson, LA

Detterman, DK

Benbow, C

Lubinski, D

Eley, T

Plomin, R

机构：

[1] Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, London SE5 8AF, England

[2] Penn State Univ, Milton S Hershey Med Ctr, Dept Immunol & Microbiol, University Pk, PA 16802 USA

[3] Univ Wales Coll Cardiff, Coll Med, Dept Med Psychol, Cardiff CF1 3NS, S Glam, Wales

[4] Case Western Reserve Univ, Dept Psychol, Cleveland, OH 44106 USA

[5] Iowa State Univ, Dept Psychol, Ames, IA 50011 USA

来源：

PSYCHOLOGICAL SCIENCE | 1998年 / 9卷 / 03期

关键词：

D O I：

10.1111/1467-9280.00032

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Quantitative trait loci (QTLs) associated with general cognitive ability (g) were investigated for several groups of children selected for very high or for average cognitive functioning. A DNA marker in the gene for insulin-like growth factor-2 receptor (IGF2R) on Chromosome 6 yielded a significantly greater frequency of a particular form of the gene (allele) in a high-g group (.303; average IQ = 136, N = 51) than in a control group (.156, average IQ = 103, N = 51). This association was replicated in an extremely-high-g group (all estimated IQs > 160, N = 52) as compared with an independent control group (average IQ = 101, N = 50), with allelic frequencies of .340 and .169, respectively. Moreover, a high-mathematics-ability group (N = 62) and a high-verbal-ability group (N = 51) yielded results that were in the same direction but only marginally significant (p = .06 and .08, respectively).

引用

页码：159 / 166

页数：8

共 36 条

[1] THE MOUSE INSULIN-LIKE GROWTH-FACTOR TYPE-2 RECEPTOR IS IMPRINTED AND CLOSELY LINKED TO THE TME LOCUS [J].