QUANTITATIVE TRAIT LOCUS FOR READING-DISABILITY ON CHROMOSOME-6

被引：422

作者：

CARDON, LR

SMITH, SD

FULKER, DW

KIMBERLING, WJ

PENNINGTON, BF

DEFRIES, JC

机构：

[1] SRI INT,HLTH SCI PROGRAM,MENLO PK,CA 94025

[2] STANFORD UNIV,DEPT MATH,STANFORD,CA 94305

[3] BOYS TOWN NATL RES HOSP,CTR HEREDITARY COMMUN DISORDERS,OMAHA,NE 68131

[4] UNIV COLORADO,INST BEHAV GENET,BOULDER,CO 80309

[5] UNIV DENVER,DEPT PSYCHOL,DENVER,CO 80208

来源：

SCIENCE | 1994年 / 266卷 / 5183期

关键词：

D O I：

10.1126/science.7939663

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Interval mapping of data from two independent samples of sib pairs, at least one member of whom was reading disabled, revealed evidence for a quantitative trait locus (QTL) on chromosome 6. Results obtained from analyses of reading performance from 114 sib pairs genotyped for DNA markers localized the QTL to 6p21.3. Analyses of corresponding data from an independent sample of 50 dizygotic twin pairs provided evidence for linkage to the same region. In combination, the replicate samples yielded a chi(2) value of 16.73 (P = 0.0002). Examination of twin and kindred siblings with more extreme deficits in reading performance yielded even stronger evidence for a QTL (chi(2) = 27.35, P < 0.00001). The position of the QTL was narrowly defined with a 100:1 confidence interval to a 2-centimorgan region within the human leukocyte antigen complex.

引用

页码：276 / 279

页数：4

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