Genetics of infectious disease resistance

被引：56

作者：

Hill, AVS

机构：

[1] Wellcome Trust Ctr. for Hum. Genet., University of Oxford, Oxford OX3 7BN, Windmill Road

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1996年 / 6卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0959-437X(96)80013-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The identification of large numbers of candidate genes and the introduction of methodologies for whole-genome screening have provided new opportunities for elucidating the molecular basis of variable susceptibility to major infectious diseases. 12 genes have been implicated in variable susceptibility to malaria and susceptibility/resistance genes for several other infectious diseases are beginning to be identified. Recent work suggests that large-scale family linkage and population association studies will be a more succesful route to human disease genes than extrapolation from mouse models of infection.

引用

收藏

页码：348 / 353

页数：6

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