Siglecs in innate immunity

被引：176

作者：

Crocker, PR ^{[1
]}

机构：

[1] Univ Dundee, Wellcome Trust Bioctr, Div Cell Biol & Immunol, Dundee DD1 5EH, Scotland

来源：

CURRENT OPINION IN PHARMACOLOGY | 2005年 / 5卷 / 04期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/j.coph.2005.03.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Siglecs are sialic acid-binding Ig-like lectins expressed in a highly specific manner, and which are implicated in signaling and adhesive functions. The CD33-related siglecs represent a distinct subgroup that is undergoing rapid evolution within the innate immune system, with the potential to trigger apoptosis and provide inhibitory signals. CD22 is a well-characterised B cell restricted siglec that has been shown to mediate both sialic acid-dependent and independent signaling functions in B cell regulation. As endocytic receptors, siglecs provide portals of entry for certain viral and bacterial pathogens, as well as therapeutic opportunities for targeting innate immune cells in disease.

引用

页码：431 / 437

页数：7

共 52 条

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