Estradiol prevents kainic acid-induced neuronal loss in the rat dentate gyrus

被引：99

作者：

Azcoitia, I ^{[1
]}

Sierra, A

Garcia-Segura, LM

机构：

[1] Univ Complutense Madrid, Fac Biol, Dept Biol Celular, E-28040 Madrid, Spain

[2] CSIC, Inst Cajal, E-28002 Madrid, Spain

来源：

NEUROREPORT | 1998年 / 9卷 / 13期

关键词：

dentate gyrus; estradiol; hippocampus; interneurons; kainic acid; neuronal death; ovariectomy; somatostatin;

D O I：

10.1097/00001756-199809140-00029

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE neuroprotective role of 17 beta-estradiol in the hippocampal dentate gyrus of adult rats treated with kainic acid has been investigated. The systemic injection of a single low dose (7 mg/kg) of kainic acid to ovariectomized rats produced a marked loss of Nissl-stained and somatostatin-immunoreactive hilar neurons. A single simultaneous systemic dose of estradiol (150 mu g per animal) prevented the kainic acid-induced decrease in Nissl-stained and somatostatinergic hilar neurons. These results indicate that estradiol may protect adult hilar neurons in vivo from neurotoxic-induced cell death. NeuroReport 9: 3075-3079 (C) 1998 Lippincott Williams & Wilkins.

引用

页码：3075 / 3079

页数：5

共 27 条

[21] Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease [J].

Tang, MX ;

Jacobs, D ;

Stern, Y ;

Marder, K ;

Schofield, P ;

Gurland, B ;

Andrews, H ;

Mayeux, R .

LANCET, 1996, 348 (9025) :429-432

[22] 17 beta-estradiol protects against NMDA-induced excitotoxicity by direct inhibition of NMDA receptors [J].

Weaver, CE ;

ParkChung, M ;

Gibbs, TT ;

Farb, DH .

BRAIN RESEARCH, 1997, 761 (02) :338-341

[23]

Weiland NG, 1997, J COMP NEUROL, V388, P603, DOI 10.1002/(SICI)1096-9861(19971201)388:4<603::AID-CNE8>3.0.CO

[24]

2-6

[25] SPECIFIC SUBUNIT MESSENGER-RNAS OF THE GABA(A) RECEPTOR ARE REGULATED BY PROGESTERONE IN SUBFIELDS OF THE HIPPOCAMPUS [J].

WEILAND, NG ;

ORCHINIK, M .

MOLECULAR BRAIN RESEARCH, 1995, 32 (02) :271-278

[26] UNBIASED STEREOLOGICAL ESTIMATION OF THE TOTAL NUMBER OF NEURONS IN THE SUBDIVISIONS OF THE RAT HIPPOCAMPUS USING THE OPTICAL FRACTIONATOR [J].

WEST, MJ ;

SLOMIANKA, L ;

GUNDERSEN, HJG .

ANATOMICAL RECORD, 1991, 231 (04) :482-497

[27]

Woolley CS, 1997, J NEUROSCI, V17, P1848

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