DISC1 (Disrupted in Schizophrenia-1) is expressed in limbic regions of the primate brain

被引：66

作者：

Austin, CP ^{[1
]}

Ma, L ^{[1
]}

Ky, B ^{[1
]}

Morris, JA ^{[1
]}

Shughrue, PJ ^{[1
]}

机构：

[1] Merck Res Labs, Dept Neurosci, W Point, PA 19486 USA

来源：

NEUROREPORT | 2003年 / 14卷 / 07期

关键词：

dentate; DISC1; gene; hippocampus; primate; schizophrenia; septum;

D O I：

10.1097/01.wnr.0000074342.81633.63

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Disrupted in Schizophrenia-1 (DISC1) was identified as truncated by a balanced translocation segregating with schizophrenia and other major mental illness in a large Scottish family. As a step in evaluating the function of DISC1 and its potential role in human schizophrenia, we have determined its regional expression in the primate brain by in situ hybridization. DISC1 expression is highly localized, with most prominent expression in the dentate gyrus of the hippocampus and lateral septum, and lower levels of expression in the cerebral cortex, amygdala, paraventricular hypothalamus, cerebellum, interpeduncular nucleus, and subthalamic nucleus. Given that many of these regions have been implicated in schizophrenia pathogenesis, these results suggest brain circuits through which DISC1 truncation may predispose to schizophrenia.

引用

页码：951 / 954

页数：4

共 19 条

[11] Compulsions, Parkinson's disease, and stimulation [J].

Mallet, L ;

Mesnage, V ;

Houeto, JL ;

Pelissolo, A ;

Yelnik, J ;

Behar, C ;

Gargiulo, M ;

Welter, ML ;

Bonnet, AM ;

Pillon, B ;

Cornu, P ;

Dormont, D ;

Pidoux, B ;

Allilaire, JF ;

Agid, Y .

LANCET, 2002, 360 (9342) :1302-1304

[12] MEDIAL TEMPORAL-LOBE STRUCTURES IN SCHIZOPHRENIA - RELATIONSHIP OF SIZE TO DURATION OF ILLNESS [J].

MARSH, L ;

SUDDATH, RL ;

HIGGINS, N ;

WEINBERGER, DR .

SCHIZOPHRENIA RESEARCH, 1994, 11 (03) :225-238

[13] Disruption of two novel genes by a translocation co-segregating with schizophrenia [J].

Millar, JK ;

Wilson-Annan, JC ;

Anderson, S ;

Christie, S ;

Taylor, MS ;

Semple, CAM ;

Devon, RS ;

St Clair, DM ;

Muir, WJ ;

Blackwood, DHR ;

Porteous, DJ .

HUMAN MOLECULAR GENETICS, 2000, 9 (09) :1415-1423

[14] Stress activation of glutamate neurotransmission in the prefrontal cortex: Implications for dopamine-associated psychiatric disorders [J].

Moghaddam, B .

BIOLOGICAL PSYCHIATRY, 2002, 51 (10) :775-787

[15] The future of genetic studies of complex human diseases [J].

Risch, N ;

Merikangas, K .

SCIENCE, 1996, 273 (5281) :1516-1517

[16] Schizophrenia: Diverse approaches to a complex disease [J].

Sawa, A ;

Snyder, SH .

SCIENCE, 2002, 296 (5568) :692-695

[17] A review of MRI findings in schizophrenia [J].

Shenton, ME ;

Dickey, CC ;

Frumin, M ;

McCarley, RW .

SCHIZOPHRENIA RESEARCH, 2001, 49 (1-2) :1-52

[18] Neuregulin 1 and susceptibility to schizophrenia [J].

Stefansson, H ;

Sigurdsson, E ;

Steinthorsdottir, V ;

Bjornsdottir, S ;

Sigmundsson, T ;

Ghosh, S ;

Brynjolfsson, J ;

Gunnarsdottir, S ;

Ivarsson, O ;

Chou, TT ;

Hjaltason, O ;

Birgisdottir, B ;

Jonsson, H ;

Gudnadottir, VG ;

Gudmundsdottir, E ;

Bjornsson, A ;

Ingvarsson, B ;

Ingason, A ;

Sigfusson, S ;

Hardardottir, H ;

Harvey, RP ;

Lai, D ;

Zhou, MD ;

Brunner, D ;

Mutel, V ;

Gonzalo, A ;

Lemke, G ;

Sainz, J ;

Johannesson, G ;

Andresson, T ;

Gudbjartsson, D ;

Manolescu, A ;

Frigge, ML ;

Gurney, ME ;

Kong, A ;

Gulcher, JR ;

Petursson, H ;

Stefansson, K .

AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 71 (04) :877-892

[19] Contributions of genetic risk and fetal hypoxia to hippocampal volume in patients with schizophrenia or schizoaffective disorder, their unaffected siblings, and healthy unrelated volunteers [J].

van Erp, TGM ;

Saleh, PA ;

Rosso, IM ;

Huttunen, M ;

Lönnqvist, J ;

Pirkola, T ;

Salonen, O ;

Valanne, L ;

Poutanen, VP ;

Standertskjöld-Nordenstam, CG ;

Cannon, TD .

AMERICAN JOURNAL OF PSYCHIATRY, 2002, 159 (09) :1514-1520

← 1 2 →