Motor excitability in a patient with a somatosensory cortex lesion

被引：23

作者：

Liepert, J ^{[1
]}

Gorsler, A ^{[1
]}

van Eimeren, T ^{[1
]}

Münchau, A ^{[1
]}

Weiller, C ^{[1
]}

机构：

[1] Univ Hamburg, Hosp Eppendorf, Dept Neurol, D-20246 Hamburg, Germany

来源：

CLINICAL NEUROPHYSIOLOGY | 2003年 / 114卷 / 06期

关键词：

transcranial magnetic stimulation; intracortical inhibition; silent period; stimulus response curve; somatosensory cortex lesion; dystonia;

D O I：

10.1016/S1388-2457(03)00062-2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: We report a patient with an ischemic lesion in right somatosensory cortex who developed dystonic posturing and pseudoathetotic involuntary left-sided finger movements during voluntary muscle contractions. Methods: Motor excitability was assessed using transcranial magnetic stimulation techniques and electrical peripheral nerve stimulation. Results obtained from abductor digiti minimi muscles of both hands were compared. Results: On the affected side, silent period duration and intracortical inhibition were reduced, indicating a loss of inhibitory properties. Intracortical facilitation was enhanced. Stimulus-response curves showed a smaller increase of motor evoked potential amplitudes when recorded during, muscle relaxation. but not during voluntary muscle activation. Conclusions: The results suggest that, under normal conditions, somatosensory cortex modifies inhibitory as well as excitatory properties in the motor system. (C) 2003 International Federation of Clinical Neurophysiology. Published by Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：1003 / 1008

页数：6

共 47 条

[21] THE CONTROL OF HAND MOVEMENTS IN A CASE OF HEMIANESTHESIA FOLLOWING A PARIETAL LESION [J].

JEANNEROD, M ;

MICHEL, F ;

PRABLANC, C .

BRAIN, 1984, 107 (SEP) :899-920

[22] GABAERGIC NEURONS AND THEIR ROLE IN CORTICAL PLASTICITY IN PRIMATES [J].

JONES, EG .

CEREBRAL CORTEX, 1993, 3 (05) :361-372

[23] CORTICOCORTICAL INHIBITION IN HUMAN MOTOR CORTEX [J].

KUJIRAI, T ;

CARAMIA, MD ;

ROTHWELL, JC ;

DAY, BL ;

THOMPSON, PD ;

FERBERT, A ;

WROE, S ;

ASSELMAN, P ;

MARSDEN, CD .

JOURNAL OF PHYSIOLOGY-LONDON, 1993, 471 :501-519

[24] FUNCTIONAL-PROPERTIES OF MONKEY MOTOR CORTEX NEURONS RECEIVING AFFERENT INPUT FROM THE HAND AND FINGERS [J].

LEMON, RN .

JOURNAL OF PHYSIOLOGY-LONDON, 1981, 311 (FEB) :497-519

[25] Orally administered atropine enhances motor cortex excitability: a transcranial magnetic stimulation study in human subjects [J].

Liepert, J ;

Schardt, S ;

Weiller, C .

NEUROSCIENCE LETTERS, 2001, 300 (03) :149-152

[26] The glutamate antagonist Riluzole suppresses intracortical facilitation [J].

Liepert, J ;

Schwenkreis, P ;

Tegenthoff, M ;

Malin, JP .

JOURNAL OF NEURAL TRANSMISSION, 1997, 104 (11-12) :1207-1214

[27] Intracortical inhibition is reduced in a patient with a lesion in the posterolateral thalamus [J].

Münchau, A ;

Orth, M ;

Rothwell, JC ;

Di Lazzaro, V ;

Oliviero, A ;

Profice, P ;

Tonali, P ;

Pramstaller, PP ;

Bhatia, KP .

MOVEMENT DISORDERS, 2002, 17 (01) :208-212

[28] Intracortical facilitation and inhibition after transcranial magnetic stimulation in conscious humans [J].

Nakamura, H ;

Kitagawa, H ;

Kawaguchi, Y ;

Tsuji, H .

JOURNAL OF PHYSIOLOGY-LONDON, 1997, 498 (03) :817-823

[29] SENSORIMOTOR DISTURBANCES IN PATIENTS WITH LESIONS OF THE PARIETAL CORTEX [J].

PAUSE, M ;

KUNESCH, E ;

BINKOFSKI, F ;

FREUND, HJ .

BRAIN, 1989, 112 :1599-1625

[30] PROJECTION FROM THE SENSORY TO THE MOTOR CORTEX IS IMPORTANT IN LEARNING MOTOR-SKILLS IN THE MONKEY [J].

PAVLIDES, C ;

MIYASHITA, E ;

ASANUMA, H .

JOURNAL OF NEUROPHYSIOLOGY, 1993, 70 (02) :733-741

← 1 2 3 4 5 →