Transforming growth factor beta in cardiovascular development and function

被引:217
作者
Azhar, M
Schultz, JEJ
Grupp, I
Dorn, GW
Meneton, P
Molin, DGM
Gittenberger-de Groot, AC
Doetschman, T [1 ]
机构
[1] Univ Cincinnati, Coll Med, Dept Mol Genet Biochem & Microbiol, Cincinnati, OH 45267 USA
[2] INSERM, U367, F-75005 Paris, France
[3] Leiden Univ, Ctr Med, Dept Anat & Embryol, NL-2300 RC Leiden, Netherlands
关键词
TGF beta; heart; vasculature; development; physiology;
D O I
10.1016/S1359-6101(03)00044-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Transforming growth factor betas (TGFbetas) are pleiotropic cytokines involved in many biological processes. Genetic engineering and tissue explanation studies have revealed specific non-overlapping roles for TGFbeta ligands and their signaling molecules in development and in normal function of the cardiovascular system in the adult. In the embryo, TGFbetas appear to be involved in epithelial-mesenchymal transformations (EMT) during endocardial cushion formation, and in epicardial epithelial-mesenchymal transformations essential for coronary vasculature, ventricular myocardial development and compaction. In the adult, TGFbetas are involved in cardiac hypertrophy, vascular remodeling and regulation of the renal renin-angiotensin system. The evidence for TGFbeta activities during cardiovascular development and physiologic function will be given and areas which need further investigation will be discussed. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码:391 / 407
页数:17
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