Chronic amphetamine facilitates immunosuppression in response to a novel aversive stimulus: Reversal by haloperidol pretreatment

被引：18

作者：

Basso, AM ^{[1
]}

Gioino, G ^{[1
]}

Molina, VA ^{[1
]}

Cancela, LM ^{[1
]}

机构：

[1] Univ Nacl Cordoba, Fac Ciencias Quim, Dept Farmacol, RA-5000 Cordoba, Argentina

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1999年 / 62卷 / 02期

关键词：

amphetamine; sensitization; stress; haloperidol; dopamine; immunosuppression; lymphocytes; delayed-type hypersensitivity reaction hemagglutinin titers; rats;

D O I：

10.1016/S0091-3057(98)00166-X

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The effect of chronic d-amphetamine sulfate (AMPH) treatment (nine daily injections, 2 mg/kg IP) on subsequent foot shock stress-induced immunological response was investigated. In addition, the potential role of a dopaminergic (DA) mechanism in the development of chronic AMPH-induced changes in stress-influenced immune responses was characterized. Exposure to foot shock stress decreased the percentage of T-lymphocytes, and reduced the delayed-type hypersensitivity reaction (DTH) in chronically AMPH-pretreated rats relative to vehicle-treated controls. Both of those stress-induced immunosuppressive responses were no longer evident when AMPH-pretreated rats were injected with haloperidol (HAL, 1 mg/kg IP) 30 min prior to each daily AMPH injection. The present findings are indicative of a modulatory role for dopamine in the facilitating process induced by AMPH on stress-induced immunosuppressive effects. (C) 1999 Elsevier Science Inc.

引用

页码：307 / 314

页数：8

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