CHRONIC RESTRAINT ATTENUATES THE IMMUNOSUPPRESSIVE RESPONSE INDUCED BY NOVEL AVERSIVE STIMULI

被引：12

作者：

BASSO, AM ^{[1
]}

DEPIANTEDEPAOLI, M ^{[1
]}

CANCELA, L ^{[1
]}

MOLINA, VA ^{[1
]}

机构：

[1] NATL UNIV CORDOBA,FAC CIENCIAS QUIM,DEPT BIOQUIM CLIN,RA-5016 CORDOBA,ARGENTINA

来源：

PHYSIOLOGY & BEHAVIOR | 1994年 / 55卷 / 06期

关键词：

T LYMPHOCYTES; B LYMPHOCYTES; DELAYED-TYPE HYPERSENSITIVITY REACTION; HEMAGGLUTININ TITER; FOOT SHOCK; CHRONIC RESTRAINT; IMMUNOSUPPRESSION; ADAPTIVE CHANGES;

D O I：

10.1016/0031-9384(94)90403-0

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

The exposure to a novel aversive event, such as foot shock, induced a decrease in the percentage of T lymphocytes and a clear reduction in the delayed-type hypersensitivity reaction (DTH). This immunosuppressive response to an acute stressor was absent in rats that were previously exposed to a chronic immobilization stress regime (2 h daily during 7 consecutive days), but was still present in animals with prior exposure to only one or three restraint sessions. No stress effect was observed in other immunologic parameters, such as the percentage of B lymphocytes or the hemagglutinin titer, in any of the experimental treatments. The possible involvement of central adaptive mechanisms in the attenuation of the immunosuppressive response induced by an acute stress is discussed.

引用

页码：1151 / 1155

页数：5

共 24 条

[1] INTERACTIONS BETWEEN THE BRAIN AND THE IMMUNE-SYSTEM [J].

ADER, R ;

FELTEN, D ;

COHEN, N .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1990, 30 :561-602

[2] CHRONIC VARIABLE STRESS FACILITATES TUMORAL GROWTH - REVERSAL BY IMIPRAMINE ADMINISTRATION [J].

BASSO, AM ;

DEPIANTEDEPAOLI, M ;

MOLINA, VA .

LIFE SCIENCES, 1992, 50 (23) :1789-1796

[3] 7-DAY VARIABLE-STRESS REGIME ALTERS CORTICAL BETA-ADRENOCEPTOR BINDING AND IMMUNOLOGICAL RESPONSES - REVERSAL BY IMIPRAMINE [J].

BASSO, AM ;

DEPIANTEDEPAOLI, M ;

CANCELA, L ;

MOLINA, V .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1993, 45 (03) :665-672

[4] CHRONIC STRESS ENHANCES APOMORPHINE-INDUCED STEREOTYPED BEHAVIOR IN MICE - INVOLVEMENT OF ENDOGENOUS OPIOIDS [J].

CABIB, S ;

PUGLISIALLEGRA, S ;

OLIVERIO, A .

BRAIN RESEARCH, 1984, 298 (01) :138-140

[5] EFFECT OF DIFFERENT RESTRAINT SCHEDULES ON THE IMMOBILITY IN THE FORCED SWIM TEST - MODULATION BY AN OPIATE MECHANISM [J].

CANCELA, LM ;

ROSSI, S ;

MOLINA, VA .

BRAIN RESEARCH BULLETIN, 1991, 26 (05) :671-675

[6] CHRONIC STRESS ATTENUATION OF ALPHA-2-ADRENOCEPTOR REACTIVITY IS REVERSED BY NALTREXONE [J].

CANCELA, LM ;

VOLOSIN, M ;

MOLINA, VA .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1988, 31 (01) :33-35

[7] REDUCED APOMORPHINE-INDUCED SEDATION FOLLOWING CHRONIC STRESS [J].

CANCELA, LM ;

MOLINA, VA .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1987, 134 (01) :117-119

[8] NERVOUS SYSTEM IMMUNE SYSTEM INTERACTIONS - AN OVERVIEW [J].

DUNN, AJ .

JOURNAL OF RECEPTOR RESEARCH, 1988, 8 (1-4) :589-607

[9] PSYCHONEUROIMMUNOLOGY FOR THE PSYCHONEUROENDOCRINOLOGIST - A REVIEW OF ANIMAL STUDIES OF NERVOUS SYSTEM-IMMUNE SYSTEM INTERACTIONS [J].

DUNN, AJ .

PSYCHONEUROENDOCRINOLOGY, 1989, 14 (04) :251-274

[10] BEHAVIORAL-INFLUENCES ON THE IMMUNE-SYSTEM - STRESS AND CONDITIONING [J].

IRWIN, J ;

LIVNAT, S .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 1987, 11 (2-3) :137-143

← 1 2 3 →