EDARAVONE ALLEVIATES DELAYED NEURONAL DEATH AND LONG-DATED COGNITIVE DYSFUNCTION OF HIPPOCAMPUS AFTER TRANSIENT FOCAL ISCHEMIA IN Wistar RAT BRAINS

被引：38

作者：

Jiao, L. ^{[1
]}

Zhang, J. ^{[1
]}

Li, Z. ^{[1
]}

Liu, H. ^{[1
]}

Chen, Y. ^{[1
]}

Xu, S. ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Dept Neurol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China

来源：

NEUROSCIENCE | 2011年 / 182卷

基金：

中国国家自然科学基金;

关键词：

ischemia; delayed neuronal death; cognitive dysfunction; inflammation; astrocyte; FREE-RADICAL SCAVENGER; CEREBRAL-ISCHEMIA; HYPOXIA-ISCHEMIA; OXYGEN RADICALS; DAMAGE; INJURY; RESPONSES; NEUROPROTECTION; INHIBITION; INFARCTION;

D O I：

10.1016/j.neuroscience.2011.01.017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Edaravone is currently being used in acute ischemic stroke both in clinical and experimental research as a potent antioxidant. Here we explore the effects of edaravone on delayed neuronal death (DND) and long-dated cognitive dysfunction of hippocampus after cerebral ischemia-reperfusion (IR) injury and explain the underlying mechanisms and pathways. Our findings suggested that edaravone not only significantly alleviated delayed neuronal death and cognitive dysfunction of hippocampus after cerebral focal ischemia, but also markedly decreased malondialdehyde (MDA) levels. In addition, edaravone increased superoxide dismutase (SOD) levels and reduced the levels of inflammatory cytokines such as IL-1 beta and TNF-alpha expression; edaravone, also suppressed glial fibrillary acidic protein (GFAP) proliferation at days 3, 7 and 30 after reperfusion. Overall, the consensus emerging from this body of data indicated that edaravone exerts a later neuroprotective effect to hippocampus through its ability to inhibit inflammation, suppression of astrocyte activation and scavenging free radicals in stroke events. (C) 2011 Published by Elsevier Ltd on behalf of IBRO.

引用

页码：177 / 183

页数：7

共 28 条

[1] STRONG ATTENUATION OF ISCHEMIC AND POSTISCHEMIC BRAIN EDEMA IN RATS BY A NOVEL FREE-RADICAL SCAVENGER [J].